145194 20260217205558.0 doi 10.1016/j.jad.2024.09.036 sideral 139982 ART-2024-139982 eng Peláez, Trinidad Efficacy of the unified protocol for transdiagnostic treatment of comorbid emotional disorders in patients with ultra high risk for psychosis: Results of a randomized controlled trial 2024 Access copy available to the general public Unrestricted Background The most common reason for help-seeking in ultra-high risk (UHR) for psychosis patients is comorbid symptoms, mainly anxiety and depression. However, psychological interventions are mainly focused on subthreshold psychotic symptoms. There is a growing push to include transdiagnostic therapies in specialized intervention teams for psychosis in young people. The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) has demonstrated efficacy in emotional disorders, and its application has recently expanded to other pathologies such as borderline personality disorder (BPD) and bipolar disorder (BD). Methods This pilot study was conducted with 36 patients with UHR for psychosis and symptoms of comorbid emotional disorders who were receiving treatment in an early intervention programme for psychosis. This is a randomised control trial (RCT) with two conditions: treatment as usual (TAU) with the group and online application of the UP (UP+TAU) (n = 18) and TAU (n = 18). Evaluations were conducted at baseline, after treatment, and at the three-month follow-up. Results Comorbid anxiety and depression symptoms improved significantly in patients in the UP+TAU group compared to those in the TAU. Significant improvements in negative affect, emotional dysregulation, neuroticism, extraversion, functioning, and quality of life were also observed, and satisfaction with the intervention was high. Conclusions UP may be an acceptable and effective intervention for the treatment of symptoms of comorbid emotional disorders in patients with UHR for psychosis. Limitations The sample size was small, and further studies are needed to test this intervention with larger samples of patients with UHR for psychosis with emotional comorbidities. info:eu-repo/grantAgreement/ES/DGA/S31-23R info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 4.9 2024 CLINICAL NEUROLOGY 33 / 286 = 0.115 2024 Q1 T1 PSYCHIATRY 33 / 288 = 0.115 2024 Q1 T1 PSYCHIATRY 33 / 288 = 0.115 2024 Q1 T1 2.121 2024 Psychiatry and Mental Health 2024 Q1 Clinical Psychology 2024 Q1 9.5 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion López-Carrilero, Raquel Espinosa, Victoria Balsells, Sol Ochoa, Susana Osma, Jorge Universidad de Zaragoza (orcid)0000-0002-7293-318X 4009 680 Universidad de Zaragoza Dpto. Psicología y Sociología Área Person.Eval.Trat.Psicoló. 367 (2024), 934-943 J. affect. disord. Journal of Affective Disorders 0165-0327 826731 http://zaguan.unizar.es/record/145194/files/texto_completo.pdf Versión publicada 2282516 http://zaguan.unizar.es/record/145194/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:145194 articulos driver 2026-02-17-20:43:45 ARTICLE