Ketogenic diet decreases alcohol intake in adult male mice

Blanco Gandía M.C. (Universidad de Zaragoza) ; Ródenas-González F. ; Pascual M. ; Reguilón M.D. ; Guerri C. ; Miñarro J. ; Rodríguez-Arias M.

Resumen: The classic ketogenic diet is a diet high in fat, low in carbohydrates, and well-adjusted proteins. The reduction in glucose levels induces changes in the body’s metabolism, since the main energy source happens to be ketone bodies. Recent studies have suggested that nutritional interventions may modulate drug addiction. The present work aimed to study the potential effects of a classic ketogenic diet in modulating alcohol consumption and its rewarding effects. Two groups of adult male mice were employed in this study, one exposed to a standard diet (SD, n = 15) and the other to a ketogenic diet (KD, n = 16). When a ketotic state was stable for 7 days, animals were exposed to the oral self-administration paradigm to evaluate the reinforcing and motivating effects of ethanol. Rt-PCR analyses were performed evaluating dopamine, adenosine, CB1, and Oprm gene expression. Our results showed that animals in a ketotic state displayed an overall decrease in ethanol consumption without changes in their motivation to drink. Gene expression analyses point to several alterations in the dopamine, adenosine, and cannabinoid systems. Our results suggest that nutritional interventions may be a useful complementary tool in treating alcohol-use disorders. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Idioma: Inglés

DOI: 10.3390/nu13072167

Año: 2021

Publicado en: Nutrients 13, 7 (2021), 2167 [16 pp]
ISSN: 2072-6643

Factor impacto JCR: 6.706 (2021)

Categ. JCR: NUTRITION & DIETETICS rank: 15 / 90 = 0.167 (2021) - Q1 - T1

Factor impacto CITESCORE: 7.9 - Nursing (Q1) - Agricultural and Biological Sciences (Q1)

Factor impacto SCIMAGO: 1.287 - Nutrition and Dietetics (Q1) - Food Science (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0017-0004
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-0007

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Psicolog.Evolut.Educac (Dpto. Psicología y Sociología)