000145331 001__ 145331
000145331 005__ 20241024135330.0
000145331 0247_ $$2doi$$a10.1016/j.aca.2024.343305
000145331 0248_ $$2sideral$$a140251
000145331 037__ $$aART-2024-140251
000145331 041__ $$aeng
000145331 100__ $$aBazo, Antonio$$uUniversidad de Zaragoza
000145331 245__ $$aIntensity- and time-based strategies for micro/nano-sizing via single-particle ICP-mass spectrometry: A comparative assessment using Au and SiO2 as model particles
000145331 260__ $$c2024
000145331 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145331 5203_ $$aBackground
Single-particle ICP-mass spectrometry (SP-ICP-MS) is a powerful method for micro/nano-particle (MNP) sizing. Despite the outstanding evolution of the technique in the last decade, most studies still rely on traditional approaches based on (1) the use of integrated intensity as the analytical signal and (2) the calculation of the transport efficiency (TE). However, the increasing availability of MNP standards and advancements in hardware and software have unveiled new venues for MNP sizing, including TE-independent and time-based approaches. This work systematically examines these different methodologies to identify and summarize their strengths and weaknesses, thus helping to determine their preferred application areas.
Results
Different SP-ICP-MS methods for MNP sizing were assessed using AuNPs (20–70 nm) and SiO2MNPs (100–1000 nm). Among TE-dependent approaches, the particle frequency method was characterized by larger uncertainties than the particle size method. The results of the latter were dependent on the appropriate selection of the reference MNP, making the use of multiple reference MNPs recommended. TE-independent methods were based on external (linear and polynomial) calibrations and a relative approach. These methods exhibited the lowest uncertainties of all the strategies evaluated. External calibrations benefited from simpler calculations, but their application could be hindered by a lack of reference MNPs within the desired size range or by the need for interpolations outside the calibration range. Finally, transit time signals are directly proportional to the MNP size rather than its mass. The time-based method demonstrated adequate performance for sizing AuNPs but failed when sizing the largest SiO2MNPs (1000 nm).
Significance and novelty
This work provides further insights into the application of different SP-ICP-MS methodologies for MNP sizing. Both TE-independent approaches and the monitoring of the transit time as the analytical signal are underused strategies; in this context, a Python script was developed for accurate transit time measurement. After 20 years of development, a quantitative comparison of the different methodologies, including the most novel approaches, is deemed necessary for further growth on solid theoretical ground.
000145331 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E43-20R$$9info:eu-repo/grantAgreement/EC/H2020/101034288/EU/International Fellowship Programme for Talent Attraction to the Campus of International Excellence Campus Iberus/IberusExperience$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101034288-IberusExperience$$9info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFANanolyme-EFA99-1$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-122455NB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2021-031093-I
000145331 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000145331 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145331 700__ $$0(orcid)0000-0002-1856-2058$$aBolea-Fernandez, Eduardo$$uUniversidad de Zaragoza
000145331 700__ $$0(orcid)0000-0001-9582-6283$$aRua-Ibarz, Ana$$uUniversidad de Zaragoza
000145331 700__ $$0(orcid)0000-0002-3916-9992$$aAramendía, Maite$$uUniversidad de Zaragoza
000145331 700__ $$0(orcid)0000-0002-7450-8769$$aResano, Martín$$uUniversidad de Zaragoza
000145331 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000145331 773__ $$g1331 (2024), 343305 [13 pp.]$$pAnal. chim. acta$$tAnalytica Chimica Acta$$x0003-2670
000145331 8564_ $$s7748619$$uhttps://zaguan.unizar.es/record/145331/files/texto_completo.pdf$$yVersión publicada
000145331 8564_ $$s1914299$$uhttps://zaguan.unizar.es/record/145331/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145331 909CO $$ooai:zaguan.unizar.es:145331$$particulos$$pdriver
000145331 951__ $$a2024-10-24-12:10:32
000145331 980__ $$aARTICLE