145366 20260217205527.0 doi 10.1167/iovs.65.12.12 sideral 140249 ART-2024-140249 eng Mechó-García, María Statistical model of ocular wavefronts with accommodation 2024 Access copy available to the general public Unrestricted Purpose: The purpose of this study was to determine the minimum number of orthonormal basis functions, applying Principal Component Analysis (PCA), to represent the most wavefront aberrations at different accommodation stages. The study also aims to generate synthetic wavefront data using these functions. Methods: Monocular wavefront data from 191 subjects (26.15 ± 5.56 years old) were measured with a Hartmann-Shack aberrometer, simulating accommodation from 0 diopters (D) to 5 D in 1 D steps. The wavefronts for each accommodative demand were rescaled for different pupil sizes: 4.66, 4.76, 4.40, 4.09, 4.07, and 3.68 mm. PCA was applied to 150 wavefront parameters (25 Zernike coefficients × 6 accommodation levels) to obtain eigenvectors for dimensional reduction. A total of 49 eigenvectors were modeled as a sum of 2 multivariate Gaussians, from which 1000 synthetic data sets were generated. Results: The first 49 eigenvectors preserved 99.97% of the original data variability. No significant differences were observed between the mean values and standard deviation of the generated and original 49 eigenvectors (two one-sided test [TOST], P > 0.05/49) and (F-test, P > 0.05/49), both with Bonferroni correction. The mean values of the generated parameters (1000) were statistically equal to those of the original data (TOST, P > 0.05/150). The variability of the generated data was similar to the original data for the most important Zernike coefficients (F-test, P > 0.05/150). Conclusions: PCA significantly reduces the dimensionality of wavefront aberration data across 6 accommodative demands, reducing the variable space by over 66%. The synthetic data generated by the proposed wavefront model for accommodation closely resemble the original clinical data. info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 956720-OBERON info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 4.7 2024 OPHTHALMOLOGY 9 / 99 = 0.091 2024 Q1 T1 1.376 2024 Ophthalmology 2024 Q1 Sensory Systems 2024 Q1 Cellular and Molecular Neuroscience 2024 Q2 6.2 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Arcas-Carbonell, María (orcid)0009-0006-7694-8086 Orduna-Hospital, Elvira Universidad de Zaragoza (orcid)0000-0003-2710-1875 Sánchez-Cano, Ana Universidad de Zaragoza (orcid)0000-0002-5621-1937 López-Gil, Norberto Macedo-de-Araújo, Rute J. Faria-Ribeiro, Miguel Fernandes, Paulo González-Méijome, José Manuel Rozema, Jos 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 65, 12 (2024), 12 [9 pp.] Investig. ophthalmol. vis. sci. Investigative ophthalmology & visual science 0146-0404 1490244 http://zaguan.unizar.es/record/145366/files/texto_completo.pdf Versión publicada 3039816 http://zaguan.unizar.es/record/145366/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:145366 articulos driver 2026-02-17-20:31:08 ARTICLE