145386 20260112133258.0 doi 10.1007/s11356-024-34983-3 sideral 140271 ART-2024-140271 eng Garralaga, Mª Pilar Assessment of oxidative stress biomarkers in Palaemon varians exposed to deep eutectic systems 2024 Access copy available to the general public Unrestricted In recent years, there has been extensive research within the scientific community on deep eutectic systems due to their remarkable versatility in solubilizing diverse substances and serving as effective solvents in catalytic processes. While initially regarded as non-toxic, a comprehensive toxicological assessment is essential to comprehend their behavior within organisms. In this study, seven distinct systems, composed of N,N,N-triethyl-N-(2,3-dihydroxypropyl)ammonium chloride (N00Cl) and glycerol-derived ethers with alkyl chains of varying lengths (100, 200, 3F00, 300, 3i00, and 400), in a 1:2 molar ratio were investigated for their aquatic toxicity in shrimp (Palaemon varians). The assessment involved analyzing oxidative stress biomarkers such as glutathione S-transferase, glutathione peroxidase, catalase, superoxide dismutase, total antioxidant capacity (TAC), and lipoperoxidation (MDA content). Results show an odd–even effect for LC50 values being N00Cl-300, the system showing higher values. Regarding oxidative stress, an imbalance between reactive oxygen species (ROS) and antioxidant capacity in the organisms has been observed, suggesting significant toxicity to shrimps due to the changes in oxidative stress biomarkers at high concentrations. However, at 100 mg/l all systems can be considered environmentally safe, and no negative impacts are expected on aquatic ecosystems. info:eu-repo/grantAgreement/ES/DGA/B58-23R info:eu-repo/grantAgreement/ES/DGA/E37-23R info:eu-repo/grantAgreement/EC/H2020/725034/EU/ When solids become liquids: natural deep eutectic solvents for chemical process engineering/Des.solve This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 725034-Des.solve info:eu-repo/grantAgreement/ES/MINECO/PID2020-125762NB-I00 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 1.004 2024 Medicine (miscellaneous) 2024 Q1 Pollution 2024 Q1 Environmental Chemistry 2024 Q2 Health, Toxicology and Mutagenesis 2024 Q2 10.6 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ferreira, Ines Lomba, Laura Pires, Elisabet Universidad de Zaragoza (orcid)0000-0002-2676-8814 Gracia-Barberán, Sara Duarte, Ana Rita C. Diniz, Mário 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 31, 47 (2024), 57959-57972 Environ. sci. pollut. res. int. Environmental Science and Pollution Research 0944-1344 3375955 http://zaguan.unizar.es/record/145386/files/texto_completo.pdf Versión publicada 2437410 http://zaguan.unizar.es/record/145386/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:145386 articulos driver 2026-01-12-12:57:29 ARTICLE