Harnessing sustainable nanoclusters for sensitive optical detection of tetracyclines and the underlying mechanism

Justo-Tirado, Miguel ; Pérez-Herráez, Irene ; Escorihuela, Jorge ; Arenal, Raúl ; Zaballos-García, Elena ; Pérez-Prieto, Julia

Resumen: Simple and rapid sensing methods for the detection of antibiotics in drinks and foods are highly desirable due to the presence of these drugs in food products, as a consequence of extensive abuse of antibiotics in livestock production. In this study, we report a facile synthesis strategy of gold nanoclusters (AuNCs) passivated with N-acetyl-L-cysteine (AuNC@NAC). This nanocluster exhibits a fluorescence emission peak at 700 nm, which gradually decreases at increasing concentrations of antibiotics, such as tetracyclines. The limit of detection (LOD) was determined to be 0.8 ppm with a linear range of 0.1–140 μM (0.04–62 ppm). This method showcased exceptional selectivity in the detection of tetracyclines compared to anions, metallic cations and amino acids. The underlying mechanism has been elucidated, and the fluorescence quenching was found to be a combination of dynamic and static quenching mechanisms, with photoinduced electron transfer (PET) identified as the primary process for dynamic quenching.

Idioma: Inglés

DOI: 10.1039/d4na00637b

Año: 2024

Publicado en: Nanoscale Advances 6, 22 (2024), 5718-5726
ISSN: 2516-0230

Factor impacto JCR: 4.6 (2024)

Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 159 / 460 = 0.346 (2024) - Q2 - T2
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 62 / 147 = 0.422 (2024) - Q2 - T2
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 75 / 239 = 0.314 (2024) - Q2 - T1

Factor impacto SCIMAGO: 0.974 - Atomic and Molecular Physics, and Optics (Q1) - Engineering (miscellaneous) (Q1) - Materials Science (miscellaneous) (Q1) - Chemistry (miscellaneous) (Q1) - Bioengineering (Q2)

Financiación: info:eu-repo/grantAgreement/ES/AEI/CEX2023-001286-S
Financiación: info:eu-repo/grantAgreement/ES/DGA/E13-23R
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1

Tipo y forma: Artículo (Versión definitiva)