000145479 001__ 145479
000145479 005__ 20241030091919.0
000145479 0247_ $$2doi$$a10.3390/ph17091203
000145479 0248_ $$2sideral$$a140330
000145479 037__ $$aART-2024-140330
000145479 041__ $$aeng
000145479 100__ $$aMartínez-Caballero, María Ángeles
000145479 245__ $$aInhibition of Nitric Oxide Synthesis Prevents the Effects of Intermittent Social Defeat on Cocaine-Induced Conditioned Place Preference in Male Mice
000145479 260__ $$c2024
000145479 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145479 5203_ $$aWe have previously observed that mice exposed to social defeat stress are more sensitive to cocaine in the conditioned place preference (CPP) paradigm. In this context, it has been suggested that the nitric oxide (NO) pathway plays a role in the effects of stress. The present study evaluates the role of a neuronal NO synthase (nNOS) inhibitor (7-nitroindazole, 7-NI) in the short- and long-term behavioural effects of intermittent social defeat (ISD). Four groups of mice were employed for the study: a control group and three stressed groups, one treated with vehicle and two treated with 7-NI (7.25 or 12.5 mg/kg). After the last episode of defeat, mice were tested in the elevated plus maze (EPM), social interaction, object recognition and tail suspension tests. Three weeks later, mice were conditioned with cocaine (1 mg/kg). Stressed mice, irrespective of the treatment received, showed anxiety in the EPM, presented a deficit of social interaction and spent less time immobile in the tail suspension test. However, only stressed mice treated with vehicle developed CPP. Thus, although 7-NI did not modify the short-term behavioural effects of ISD, it prevented ISD-induced potentiation of the rewarding properties of cocaine in adulthood. These results support a specific role of nNOS in the effects of social stress on drug reward.
000145479 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00
000145479 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000145479 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145479 700__ $$aGarcía-Pardo, María Pilar$$uUniversidad de Zaragoza
000145479 700__ $$aCalpe-López, Claudia
000145479 700__ $$aArenas, María Carmen
000145479 700__ $$aManzanedo, Carmen
000145479 700__ $$aAguilar, María Asuncion
000145479 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000145479 773__ $$g17, 9 (2024), 1203 [18 pp.]$$pPharmaceuticals$$tPharmaceuticals$$x1424-8247
000145479 8564_ $$s1646346$$uhttps://zaguan.unizar.es/record/145479/files/texto_completo.pdf$$yVersión publicada
000145479 8564_ $$s2761677$$uhttps://zaguan.unizar.es/record/145479/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145479 909CO $$ooai:zaguan.unizar.es:145479$$particulos$$pdriver
000145479 951__ $$a2024-10-30-08:49:17
000145479 980__ $$aARTICLE