000145503 001__ 145503
000145503 005__ 20241108105821.0
000145503 0247_ $$2doi$$a10.1017/S1751731117000398
000145503 0248_ $$2sideral$$a99767
000145503 037__ $$aART-2017-99767
000145503 041__ $$aeng
000145503 100__ $$0(orcid)0000-0001-9869-524X$$aGonzález-Rodríguez, A.
000145503 245__ $$aGenomic differentiation between Asturiana de los Valles, Avileña-Negra Ibérica, Bruna dels Pirineus, Morucha, Pirenaica, Retinta and Rubia Gallega cattle breeds
000145503 260__ $$c2017
000145503 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145503 5203_ $$aThe Spanish local beef cattle breeds have most likely common origin followed by a process of differentiation. This particular historical evolution has most probably left detectable signatures in the genome. The objective of this study was to identify genomic regions associated with differentiation processes in seven Spanish autochthonous populations (Asturiana de los Valles (AV), Avileña-Negra Ibérica (ANI), Bruna dels Pirineus (BP), Morucha (Mo), Pirenaica (Pi), Retinta (Re) and Rubia Gallega (RG)). The BovineHD 777K BeadChip was used on 342 individuals (AV, n=50; ANI, n=48; BP, n=50; Mo, n=50; Pi, n=48; Re, n=48; RG, n=48) chosen to be as unrelated as possible. We calculated the fixation index (F ST) and performed a Bayesian analysis named SelEstim. The output of both procedures was very similar, although the Bayesian analysis provided a richer inference and allowed us to calculate significance thresholds by generating a pseudo-observed data set from the estimated posterior distributions. We identified a very large number of genomic regions, but when a very restrictive significance threshold was applied these regions were reduced to only 10. Among them, four regions can be highlighted because they comprised a large number of single nucleotide polymorphisms and showed extremely high signals (Kullback–Leiber divergence (KLD)>6). They are located in BTA 2 (5 575 950 to 10 152 228 base pairs (bp)), BTA 5 (17 596 734 to 18 850 702 bp), BTA 6 (37 853 912 to 39 441 548 bp) and BTA 18 (13 345 515 to 15 243 838 bp) and harbor, among others, the MSTN (Myostatin), KIT-LG (KIT Ligand), LAP3 (leucine aminopeptidase 3), NAPCG (non-SMC condensing I complex, subunit G), LCORL (ligand dependent nuclear receptor corepressor-like) and MC1R (Melanocortin 1 receptor) genes. Knowledge on these genomic regions allows to identify potential targets of recent selection and helps to define potential candidate genes associated with traits of interest, such as coat color, muscle development, fertility, growth, carcass and immunological response.
000145503 536__ $$9info:eu-repo/grantAgreement/EC/FP7/289592/EU/Next generation European system for cattle improvement and management/GENE2FARM$$9info:eu-repo/grantAgreement/ES/MICINN/AGL2010-15903$$9info:eu-repo/grantAgreement/ES/MINECO/BES-2011-045434
000145503 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000145503 590__ $$a1.87$$b2017
000145503 591__ $$aVETERINARY SCIENCES$$b24 / 139 = 0.173$$c2017$$dQ1$$eT1
000145503 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b10 / 59 = 0.169$$c2017$$dQ1$$eT1
000145503 592__ $$a0.842$$b2017
000145503 593__ $$aAnimal Science and Zoology$$c2017$$dQ1
000145503 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145503 700__ $$aMunilla, S.
000145503 700__ $$0(orcid)0000-0002-1335-7610$$aMouresan, E.F.
000145503 700__ $$aCañas-Álvarez, J.J.
000145503 700__ $$aBaro, J.A.
000145503 700__ $$aMolina, A.
000145503 700__ $$aDíaz, C.
000145503 700__ $$0(orcid)0000-0002-3042-2250$$aAltarriba, J.$$uUniversidad de Zaragoza
000145503 700__ $$aPiedrafita, J.
000145503 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, L.$$uUniversidad de Zaragoza
000145503 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000145503 773__ $$g11, 10 (2017), 1667-1679$$pAnimal$$tANIMAL$$x1751-7311
000145503 8564_ $$s1879119$$uhttps://zaguan.unizar.es/record/145503/files/texto_completo.pdf$$yVersión publicada
000145503 8564_ $$s2847180$$uhttps://zaguan.unizar.es/record/145503/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145503 909CO $$ooai:zaguan.unizar.es:145503$$particulos$$pdriver
000145503 951__ $$a2024-11-08-10:36:52
000145503 980__ $$aARTICLE