000145537 001__ 145537
000145537 005__ 20241108105821.0
000145537 0247_ $$2doi$$a10.1021/acs.inorgchem.4c02988
000145537 0248_ $$2sideral$$a140415
000145537 037__ $$aART-2024-140415
000145537 041__ $$aeng
000145537 100__ $$aSaez, Javier
000145537 245__ $$aGold(I) complexes based on nonsteroidal anti-inflammatory derivatives as multi-target drugs against colon cancer
000145537 260__ $$c2024
000145537 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145537 5203_ $$aTargeting inflammation and the molecules involved in the inflammatory process could be an effective cancer prevention and therapy strategy. Therefore, the use of anti-inflammatory strategies, such as NSAIDs and metal-based drugs, has become a promising approach for preventing and treating cancer by targeting multiple pathways involved in tumor progression. The present work describes new phosphane gold(I) complexes derived from nonsteroidal anti-inflammatory drugs as multitarget drugs against colon cancer. The antiproliferative effect of the most active complexes, [Au(L3)(JohnPhos)] (3b), [Au(L4)(CyJohnPhos)] (4a) and [Au(L4)(JohnPhos)] (4b) against colon cancer cells (Caco2-/TC7) seems to be mediated by the inhibition of the enzyme cyclooxygenase-1/2, modulation of reactive oxygen species levels by targeting thioredoxin reductase (TrxR) activity, and induction of apoptosis in cancer cells. Additionally, the three complexes exhibit high selectivity index values toward noncancerous cells. The research highlights the importance of maintaining cellular redox balance and the role of TrxR in cancer cell survival.
000145537 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B16-23R$$9info:eu-repo/grantAgreement/ES/DGA/E07-23R$$9info:eu-repo/grantAgreement/ES/ISCIII-CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/MICINN AEI/PID2022-136861NB-I00$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/NEWPOWER-S1-1.1-E01116
000145537 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000145537 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145537 700__ $$0(orcid)0009-0001-5345-6947$$aQuero, Javier$$uUniversidad de Zaragoza
000145537 700__ $$0(orcid)0000-0002-3595-7668$$aRodriguez-Yoldi, María Jesús$$uUniversidad de Zaragoza
000145537 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M. Concepción
000145537 700__ $$0(orcid)0000-0003-2457-3674$$aCerrada, Elena$$uUniversidad de Zaragoza
000145537 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000145537 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000145537 773__ $$g63, 42 (2024), 19769-19782$$pInorg. chem.$$tInorganic Chemistry$$x0020-1669
000145537 8564_ $$s3397091$$uhttps://zaguan.unizar.es/record/145537/files/texto_completo.pdf$$yVersión publicada
000145537 8564_ $$s3239278$$uhttps://zaguan.unizar.es/record/145537/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145537 909CO $$ooai:zaguan.unizar.es:145537$$particulos$$pdriver
000145537 951__ $$a2024-11-08-10:37:35
000145537 980__ $$aARTICLE