145537 20260217205536.0 doi 10.1021/acs.inorgchem.4c02988 sideral 140415 ART-2024-140415 eng Saez, Javier Gold(I) complexes based on nonsteroidal anti-inflammatory derivatives as multi-target drugs against colon cancer 2024 Access copy available to the general public Unrestricted Targeting inflammation and the molecules involved in the inflammatory process could be an effective cancer prevention and therapy strategy. Therefore, the use of anti-inflammatory strategies, such as NSAIDs and metal-based drugs, has become a promising approach for preventing and treating cancer by targeting multiple pathways involved in tumor progression. The present work describes new phosphane gold(I) complexes derived from nonsteroidal anti-inflammatory drugs as multitarget drugs against colon cancer. The antiproliferative effect of the most active complexes, [Au(L3)(JohnPhos)] (3b), [Au(L4)(CyJohnPhos)] (4a) and [Au(L4)(JohnPhos)] (4b) against colon cancer cells (Caco2-/TC7) seems to be mediated by the inhibition of the enzyme cyclooxygenase-1/2, modulation of reactive oxygen species levels by targeting thioredoxin reductase (TrxR) activity, and induction of apoptosis in cancer cells. Additionally, the three complexes exhibit high selectivity index values toward noncancerous cells. The research highlights the importance of maintaining cellular redox balance and the role of TrxR in cancer cell survival. info:eu-repo/grantAgreement/ES/DGA/B16-23R info:eu-repo/grantAgreement/ES/DGA/E07-23R info:eu-repo/grantAgreement/ES/ISCIII-CIBERObn/CB06-03-1012 info:eu-repo/grantAgreement/ES/MICINN AEI/PID2022-136861NB-I00 info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/NEWPOWER-S1-1.1-E01116 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 4.7 2024 CHEMISTRY, INORGANIC & NUCLEAR 6 / 43 = 0.14 2024 Q1 T1 0.958 2024 Chemistry (miscellaneous) 2024 Q1 Physical and Theoretical Chemistry 2024 Q1 Inorganic Chemistry 2024 Q1 7.4 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Quero, Javier Universidad de Zaragoza (orcid)0009-0001-5345-6947 Rodriguez-Yoldi, María Jesús Universidad de Zaragoza (orcid)0000-0002-3595-7668 Gimeno, M. Concepción (orcid)0000-0003-0553-0695 Cerrada, Elena Universidad de Zaragoza (orcid)0000-0003-2457-3674 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 63, 42 (2024), 19769-19782 Inorg. chem. Inorganic Chemistry 0020-1669 3397091 http://zaguan.unizar.es/record/145537/files/texto_completo.pdf Versión publicada 3239278 http://zaguan.unizar.es/record/145537/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:145537 articulos driver 2026-02-17-20:34:32 ARTICLE