000145558 001__ 145558
000145558 005__ 20241108105822.0
000145558 0247_ $$2doi$$a10.1371/journal.pone.0297702
000145558 0248_ $$2sideral$$a140409
000145558 037__ $$aART-2024-140409
000145558 041__ $$aeng
000145558 100__ $$aRuiz-Baena, José María
000145558 245__ $$aInfluence of social determinants of health on quality of life in patients with multimorbidity and polypharmacy
000145558 260__ $$c2024
000145558 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145558 5203_ $$aBackground: Multimorbidity is one of the biggest challenges faced by modern medicine, especially when managing older patients who are also often taking multiple medications. Multimorbidity is influenced by social determinants of health, giving rise to health inequalities in the population. Here, we sought to determine the influence of social determinants of health on quality of life in patients with multimorbidity and polypharmacy. Methods and materials: This cross-sectional observational study included 573 patients aged 65–74 with multimorbidity (≥3 diseases) and polypharmacy (≥5 drugs). Corresponding data was taken drawn from the Spanish MULTIPAP study, and included social and demographic variables, and data on health-related quality of life and overall self-perceived health status, assessed using the 5-level version of the EuroQol 5-dimensional questionnaire (EQ-5D-5L). Descriptive, bivariate and multivariate analyses with logistic regression models were performed. Results: Mean patient age was 69.7 years, 55.8% of patients were female, 59.7% belonged to low social classes (V, VI), a monthly income of €1051–€1850 predominated, and the median number of diseases in the same patient was 6. Factors associated with higher quality of life were (odds ratio, OR) male gender (OR = 1.599, p = 0.013), a higher educational level (OR = 1.991, p = 0.036), an absence of urban vulnerability (OR = 1.605, p = 0.017), and the presence of medium social support (OR = 1.689, p = 0.017). Having a higher number of diseases was associated with poorer quality of life (OR = 0.912, p = 0.017). Conclusions: Our findings describe associations between social determinants of health and quality of life in patients aged 65–74 years with multimorbidity and polypharmacy. More illnesses, female gender, a lower education level, urban vulnerability, and less social support are associated with poorer quality of life, underscoring the need for a biopsychosocial approach in patient care.
000145558 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B01-23R$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00276$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00572$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00996$$9info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0015$$9info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0019$$9info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0027
000145558 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000145558 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145558 700__ $$aMoreno-Juste, Aida
000145558 700__ $$0(orcid)0000-0002-5119-5093$$aPoblador-Plou, Beatriz
000145558 700__ $$aCastillo-Jimena, Marcos
000145558 700__ $$0(orcid)0000-0001-9064-9222$$aCalderón-Larrañaga, Amaia
000145558 700__ $$aLozano-Hernández, Cristina
000145558 700__ $$0(orcid)0000-0002-5440-1710$$aGimeno-Miguel, Antonio
000145558 700__ $$0(orcid)0000-0003-2928-6623$$aGimeno-Feliú, Luis A.$$uUniversidad de Zaragoza
000145558 700__ $$aAza-Pascual-Salcedo, Mercedes
000145558 700__ $$0(orcid)0000-0003-2580-2002$$aGonzález-Rubio, Francisca
000145558 700__ $$aPico-Soler, Victoria
000145558 700__ $$0(orcid)0000-0001-9466-3902$$aAbad-Díez, José María
000145558 700__ $$aBandrés-Liso, María Cristina
000145558 700__ $$aClerencia-Sierra, Mercedes
000145558 700__ $$aMarta-Moreno, Javier
000145558 700__ $$aPoncel-Falcó, Antonio
000145558 700__ $$aMultipap-Group
000145558 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000145558 773__ $$g19, 9 (2024), e0297702 [15 pp.]$$pPLoS One$$tPLoS ONE$$x1932-6203
000145558 8564_ $$s501582$$uhttps://zaguan.unizar.es/record/145558/files/texto_completo.pdf$$yVersión publicada
000145558 8564_ $$s2382273$$uhttps://zaguan.unizar.es/record/145558/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145558 909CO $$ooai:zaguan.unizar.es:145558$$particulos$$pdriver
000145558 951__ $$a2024-11-08-10:37:59
000145558 980__ $$aARTICLE