doi:10.1016/j.heliyon.2024.e39350engAdwan, LaraDotor, LauraPino, María GracielaGil, AdrianaMartin, SantiagoCea, PilarInterfacial insights: [6]-Gingerol monolayers at the air-water interface and beyondART-2024-140378Ginger is a culinary spice with a millennia-old tradition due to its extensive therapeutic applications, recently validated by scientific studies. In particular [6]-Gingerol, a key active molecule in ginger, exhibits extraordinary capabilities in addressing a wide spectrum of health issues. However, its therapeutic potential is limited by its rather low bioavailability. The incorporation of [6]-Gingerol into membrane systems of liposomes, micelles, or exosomes is a promising strategy to overcome this limitation. In this contribution, we report the hitherto unexplored surface properties of [6]-Gingerol at the air-water interface. Our comprehensive study, which includes a detailed analysis of surface pressure and surface potential vs. area per molecule isotherms, surface compression modulus, and Brewster Angle Microscopy, demonstrates the capability of [6]-Gingerol to form Langmuir films. These films can be transferred onto solid substrates, forming remarkably homogeneous Langmuir-Blodgett films which have been characterized by Quartz Crystal Microbalance and Atomic Force Microscopy. This study may be of interest as it paves the way for future research on introducing [6]-Gingerol into membrane systems and transporting it into living cells.2024http://zaguan.unizar.es/record/14557410.1016/j.heliyon.2024.e39350http://zaguan.unizar.es/record/145574oai:zaguan.unizar.es:145574info:eu-repo/grantAgreement/ES/DGA/E31-23RHeliyon 10, 20 (2024), e39350 [9 pp.]by-nc-ndhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.esinfo:eu-repo/semantics/openAccess