145574 20260217205604.0 doi 10.1016/j.heliyon.2024.e39350 sideral 140378 ART-2024-140378 eng Adwan, Lara Interfacial insights: [6]-Gingerol monolayers at the air-water interface and beyond 2024 Access copy available to the general public Unrestricted Ginger is a culinary spice with a millennia-old tradition due to its extensive therapeutic applications, recently validated by scientific studies. In particular [6]-Gingerol, a key active molecule in ginger, exhibits extraordinary capabilities in addressing a wide spectrum of health issues. However, its therapeutic potential is limited by its rather low bioavailability. The incorporation of [6]-Gingerol into membrane systems of liposomes, micelles, or exosomes is a promising strategy to overcome this limitation. In this contribution, we report the hitherto unexplored surface properties of [6]-Gingerol at the air-water interface. Our comprehensive study, which includes a detailed analysis of surface pressure and surface potential vs. area per molecule isotherms, surface compression modulus, and Brewster Angle Microscopy, demonstrates the capability of [6]-Gingerol to form Langmuir films. These films can be transferred onto solid substrates, forming remarkably homogeneous Langmuir-Blodgett films which have been characterized by Quartz Crystal Microbalance and Atomic Force Microscopy. This study may be of interest as it paves the way for future research on introducing [6]-Gingerol into membrane systems and transporting it into living cells. info:eu-repo/grantAgreement/ES/DGA/E31-23R info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 3.6 2024 MULTIDISCIPLINARY SCIENCES 29 / 136 = 0.213 2024 Q1 T1 0.644 2024 Multidisciplinary 2024 Q1 4.1 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Dotor, Laura Universidad de Zaragoza Pino, María Graciela Gil, Adriana Martin, Santiago Universidad de Zaragoza (orcid)0000-0001-9193-3874 Cea, Pilar Universidad de Zaragoza (orcid)0000-0002-4729-9578 2012 755 Universidad de Zaragoza Dpto. Química Física Área Química Física 10, 20 (2024), e39350 [9 pp.] Heliyon Heliyon 2405-8440 5464520 http://zaguan.unizar.es/record/145574/files/texto_completo.pdf Versión publicada 1956871 http://zaguan.unizar.es/record/145574/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:145574 articulos driver 2026-02-17-20:46:01 ARTICLE