000145587 001__ 145587
000145587 005__ 20260217205604.0
000145587 0247_ $$2doi$$a10.1021/acsomega.4c02838
000145587 0248_ $$2sideral$$a140467
000145587 037__ $$aART-2024-140467
000145587 041__ $$aeng
000145587 100__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, Maria$$uUniversidad de Zaragoza
000145587 245__ $$aTwo Different Responsive Organosilica Nanocarriers to Combine Chemo- and Immunotherapy against Cancer
000145587 260__ $$c2024
000145587 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145587 5203_ $$aThe combination of chemo- and immunotherapy was recently demonstrated to improve a patient’s response to therapy, giving rise to an emerging cancer treatment known as chemoimmunotherapy (CIT). Despite the promising benefits of CIT, the most important challenges are (i) the simultaneous or time-controlled delivery of two drugs and (ii) the selective uptake into different cells for each of the drugs: cancer cells for the chemotherapeutic and macrophages for the immunostimulation actives. Herein, a delivery strategy based on morphologically different stimuli-responsive breakable organosilica nanocarriers is exploited to transport two distinct drugs in the different cells using different times of delivery. We employ stimulus-sensitive, PEGylated organosilica nanocages to encapsulate the chemotherapeutic agent doxorubicin, which is preferentially taken up by tumor cells vs macrophages. On the other hand, similar size mesoporous organosilica nanoparticles, preferentially internalized by macrophages, are filled with the immunostimulator resiquimod. The administration in a sequential manner of the two different nanocarriers allowed us to assess the integrated effect of the combined therapy versus treatment with a single drug. In vitro work clearly shows an important reduction of tumor cell viability when both chemo- and immunotherapeutic agents are delivered.
000145587 536__ $$9info:eu-repo/grantAgreement/EC/H2020/964386/EU/A key to the rational design of extracellular vesicles-mimicking nanoparticles/MIMIC-KeY$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 964386-MIMIC-KeY
000145587 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000145587 590__ $$a4.3$$b2024
000145587 592__ $$a0.773$$b2024
000145587 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b81 / 239 = 0.339$$c2024$$dQ2$$eT2
000145587 593__ $$aChemical Engineering (miscellaneous)$$c2024$$dQ1
000145587 593__ $$aChemistry (miscellaneous)$$c2024$$dQ2
000145587 594__ $$a7.1$$b2024
000145587 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145587 700__ $$aFenaroli, Alessia Lucrezia
000145587 700__ $$aScaccaglia, Mirco
000145587 700__ $$aMatteo, Cristina
000145587 700__ $$aGrasselli, Chiara
000145587 700__ $$aZucchetti, Massimo
000145587 700__ $$aFrapolli, Roberta
000145587 700__ $$aNastasi, Claudia
000145587 700__ $$aDe Cola, Luisa
000145587 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000145587 773__ $$g9, 40 (2024), 41225-41235$$pACS Omega$$tACS OMEGA$$x2470-1343
000145587 8564_ $$s7033024$$uhttps://zaguan.unizar.es/record/145587/files/texto_completo.pdf$$yVersión publicada
000145587 8564_ $$s3249994$$uhttps://zaguan.unizar.es/record/145587/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145587 909CO $$ooai:zaguan.unizar.es:145587$$particulos$$pdriver
000145587 951__ $$a2026-02-17-20:46:09
000145587 980__ $$aARTICLE