145587 20260217205604.0 doi 10.1021/acsomega.4c02838 sideral 140467 ART-2024-140467 eng Sancho-Albero, Maria Universidad de Zaragoza (orcid)0000-0001-8762-5457 Two Different Responsive Organosilica Nanocarriers to Combine Chemo- and Immunotherapy against Cancer 2024 Access copy available to the general public Unrestricted The combination of chemo- and immunotherapy was recently demonstrated to improve a patient’s response to therapy, giving rise to an emerging cancer treatment known as chemoimmunotherapy (CIT). Despite the promising benefits of CIT, the most important challenges are (i) the simultaneous or time-controlled delivery of two drugs and (ii) the selective uptake into different cells for each of the drugs: cancer cells for the chemotherapeutic and macrophages for the immunostimulation actives. Herein, a delivery strategy based on morphologically different stimuli-responsive breakable organosilica nanocarriers is exploited to transport two distinct drugs in the different cells using different times of delivery. We employ stimulus-sensitive, PEGylated organosilica nanocages to encapsulate the chemotherapeutic agent doxorubicin, which is preferentially taken up by tumor cells vs macrophages. On the other hand, similar size mesoporous organosilica nanoparticles, preferentially internalized by macrophages, are filled with the immunostimulator resiquimod. The administration in a sequential manner of the two different nanocarriers allowed us to assess the integrated effect of the combined therapy versus treatment with a single drug. In vitro work clearly shows an important reduction of tumor cell viability when both chemo- and immunotherapeutic agents are delivered. info:eu-repo/grantAgreement/EC/H2020/964386/EU/A key to the rational design of extracellular vesicles-mimicking nanoparticles/MIMIC-KeY This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 964386-MIMIC-KeY info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 4.3 2024 CHEMISTRY, MULTIDISCIPLINARY 81 / 239 = 0.339 2024 Q2 T2 0.773 2024 Chemical Engineering (miscellaneous) 2024 Q1 Chemistry (miscellaneous) 2024 Q2 7.1 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Fenaroli, Alessia Lucrezia Scaccaglia, Mirco Matteo, Cristina Grasselli, Chiara Zucchetti, Massimo Frapolli, Roberta Nastasi, Claudia De Cola, Luisa 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 9, 40 (2024), 41225-41235 ACS Omega ACS OMEGA 2470-1343 7033024 http://zaguan.unizar.es/record/145587/files/texto_completo.pdf Versión publicada 3249994 http://zaguan.unizar.es/record/145587/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:145587 articulos driver 2026-02-17-20:46:09 ARTICLE