000145633 001__ 145633
000145633 005__ 20241114112316.0
000145633 0247_ $$2doi$$a10.1002/dad2.12610
000145633 0248_ $$2sideral$$a140552
000145633 037__ $$aART-2024-140552
000145633 041__ $$aeng
000145633 100__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, Patricia$$uUniversidad de Zaragoza
000145633 245__ $$aMild behavioral impairment in the general population aged 55+ and its association with incident dementia
000145633 260__ $$c2024
000145633 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145633 5203_ $$aThis study aimed to investigate the dementia risk associated with mild behavioral impairment (MBI) and its domains in older community‐dwelling individuals. A total 4803 community‐dwelling individuals aged over 55 years were followed for 4.5 years (ZARADEMP study). MBI was assessed according to the International Society to Advance Alzheimer's Research and Treatment (ISTAART) diagnostic criteria using the Geriatric Mental State (GMS). Odds ratios (OR) for incident dementia and Alzheimer's disease (AD) were determined using logistic regression models adjusted for potential confounders (such as age, disability, or vascular disease). In cognitively normal individuals, decreased motivation was the only MBI domain that was associated with an increased risk of all‐cause dementia (OR: 2.30 [95% confidence interval {CI}: 1.16‐4.61]) in multivariable analyses, although the increase in the risk of AD was not statistically significant. Our findings suggest that decreased motivation may be a phenotypic marker for individuals at risk of dementia. Further research is required to evaluate the association between MBI domains and different types of dementia.
000145633 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B15-17R$$9info:eu-repo/grantAgreement/ES/DGA/B15-23R$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562
000145633 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000145633 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145633 700__ $$0(orcid)0000-0002-3360-7015$$aLópez-Antón, Raúl$$uUniversidad de Zaragoza
000145633 700__ $$0(orcid)0000-0003-2284-7862$$aCámara, Concepción de la$$uUniversidad de Zaragoza
000145633 700__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, Javier$$uUniversidad de Zaragoza
000145633 700__ $$0(orcid)0000-0002-1252-2397$$aLobo, Elena$$uUniversidad de Zaragoza
000145633 700__ $$0(orcid)0000-0003-3025-8048$$aLobo, Antonio$$uUniversidad de Zaragoza
000145633 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000145633 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000145633 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000145633 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000145633 773__ $$g16 (2024), e12610 [10 pp.]$$tAlzheimer's and dementia. Diagnosis, assessment and disease monitoring$$x2352-8729
000145633 8564_ $$s642926$$uhttps://zaguan.unizar.es/record/145633/files/texto_completo.pdf$$yVersión publicada
000145633 8564_ $$s2173381$$uhttps://zaguan.unizar.es/record/145633/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145633 909CO $$ooai:zaguan.unizar.es:145633$$particulos$$pdriver
000145633 951__ $$a2024-11-14-10:18:21
000145633 980__ $$aARTICLE