145633 20260219090937.0 doi 10.1002/dad2.12610 sideral 140552 ART-2024-140552 eng Gracia-García, Patricia Universidad de Zaragoza (orcid)0000-0001-9822-6312 Mild behavioral impairment in the general population aged 55+ and its association with incident dementia 2024 Access copy available to the general public Unrestricted This study aimed to investigate the dementia risk associated with mild behavioral impairment (MBI) and its domains in older community‐dwelling individuals. A total 4803 community‐dwelling individuals aged over 55 years were followed for 4.5 years (ZARADEMP study). MBI was assessed according to the International Society to Advance Alzheimer's Research and Treatment (ISTAART) diagnostic criteria using the Geriatric Mental State (GMS). Odds ratios (OR) for incident dementia and Alzheimer's disease (AD) were determined using logistic regression models adjusted for potential confounders (such as age, disability, or vascular disease). In cognitively normal individuals, decreased motivation was the only MBI domain that was associated with an increased risk of all‐cause dementia (OR: 2.30 [95% confidence interval {CI}: 1.16‐4.61]) in multivariable analyses, although the increase in the risk of AD was not statistically significant. Our findings suggest that decreased motivation may be a phenotypic marker for individuals at risk of dementia. Further research is required to evaluate the association between MBI domains and different types of dementia. info:eu-repo/grantAgreement/ES/DGA/B15-17R info:eu-repo/grantAgreement/ES/DGA/B15-23R info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255 info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815 info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617 info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562 info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 4.4 2024 1.69 2024 Psychiatry and Mental Health 2024 Q1 Neurology (clinical) 2024 Q1 7.0 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion López-Antón, Raúl Universidad de Zaragoza (orcid)0000-0002-3360-7015 Cámara, Concepción de la Universidad de Zaragoza (orcid)0000-0003-2284-7862 Santabárbara, Javier Universidad de Zaragoza (orcid)0000-0002-7297-6104 Lobo, Elena Universidad de Zaragoza (orcid)0000-0002-1252-2397 Lobo, Antonio Universidad de Zaragoza (orcid)0000-0003-3025-8048 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 16 (2024), e12610 [10 pp.] Alzheimer's and dementia. Diagnosis, assessment and disease monitoring 2352-8729 642926 http://zaguan.unizar.es/record/145633/files/texto_completo.pdf Versión publicada 2173381 http://zaguan.unizar.es/record/145633/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:145633 articulos driver 2026-02-19-09:00:35 ARTICLE