000145694 001__ 145694 000145694 005__ 20241122130823.0 000145694 0247_ $$2doi$$a10.3390/opt5040031 000145694 0248_ $$2sideral$$a140676 000145694 037__ $$aART-2024-140676 000145694 041__ $$aeng 000145694 100__ $$0(orcid)0000-0002-9068-7728$$aÁvila, Francisco J.$$uUniversidad de Zaragoza 000145694 245__ $$aA Review of Non-Linear Optical Imaging Techniques for Cancer Detection 000145694 260__ $$c2024 000145694 5060_ $$aAccess copy available to the general public$$fUnrestricted 000145694 5203_ $$aThe World Health Organization (WHO) cancer agency predicts that more than 35 million cases of cancer will be experienced in 2050, a 77% increase over the 2022 estimate. Currently, the main cancers diagnosed are breast, lung, and colorectal. There is no standardized tool for cancer diagnoses; initially, clinical procedures are guided by the patient symptoms and usually involve biochemical blood tests, imaging, and biopsy. Label-free non-linear optical approaches are promising tools for tumor imaging, due to their inherent non-invasive biosafe contrast mechanisms and the ability to monitor collagen-related disorders, and biochemical and metabolic changes during cancer progression. In this review, the main non-linear microscopy techniques are discussed, according to three main contrast mechanisms: biochemical, metabolic, and structural imaging. 000145694 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000145694 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000145694 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica 000145694 773__ $$g5, 4 (2024), 416-433$$pOptics (Basel)$$tOptics (Basel)$$x2673-3269 000145694 8564_ $$s7385963$$uhttps://zaguan.unizar.es/record/145694/files/texto_completo.pdf$$yVersión publicada 000145694 8564_ $$s2534258$$uhttps://zaguan.unizar.es/record/145694/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000145694 909CO $$ooai:zaguan.unizar.es:145694$$particulos$$pdriver 000145694 951__ $$a2024-11-22-11:52:45 000145694 980__ $$aARTICLE