000145724 001__ 145724
000145724 005__ 20260112133353.0
000145724 0247_ $$2doi$$a10.3390/metabo14110618
000145724 0248_ $$2sideral$$a140648
000145724 037__ $$aART-2024-140648
000145724 041__ $$aeng
000145724 100__ $$aEspina, Silvia$$uUniversidad de Zaragoza
000145724 245__ $$aUnraveling the Association of Liver Steatosis and Fibrosis with Vitamin B12: A Cross-Sectional Study
000145724 260__ $$c2024
000145724 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145724 5203_ $$aBackground: There are conflicting studies reporting both an increase and a decrease in vitamin B12 (VB12) levels in non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to dissect the effects of steatosis and fibrosis on VB12. Methods: This is a cross-sectional study including all patients with a vibration-controlled transient elastography (VCTE) performed at the Hospital Miguel Servet (Zaragoza, Spain) between 2019 and 2022 for a chronic liver disease and having a recent blood test for VB12 levels. Liver fibrosis was assessed by VCTE and hepatic steatosis by ultrasonography and/or through controlled attenuation parameter (CAP). Results: 1195 patients (NAFLD n = 441, other chronic liver disease n = 754) were included. Median age was 57 years, 53% female. Patients with NAFLD had lower levels of VB12 compared to the rest of chronic liver diseases (289 vs. 313 pg/mL, p < 0.001). A significant negative correlation was observed between VB12 levels and hepatic steatosis measured by CAP (r = −0.13, p < 0.001). A significant positive correlation was observed between VB12 levels and liver stiffness in patients with NAFLD in both sexes (men r = 0.31, p < 0.001 and women r = 0.15, p = 0.016). A significant association between VB12 levels and liver fibrosis in cirrhosis stage was observed in patients with NAFLD (OR 1.06, 95% CI, 1.025–1.098, p = 0.001). Conclusion: VB12 levels were lower with greater hepatic steatosis. In NAFLD, VB12 levels were lower compared to other chronic liver diseases but their levels increased with higher liver stiffness and in cirrhosis stage.
000145724 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B03-23R$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-01366$$9info:eu-repo/grantAgreement/ES/ISCIII/PMP21-00094
000145724 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000145724 590__ $$a3.7$$b2024
000145724 592__ $$a0.996$$b2024
000145724 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b124 / 319 = 0.389$$c2024$$dQ2$$eT2
000145724 593__ $$aBiochemistry$$c2024$$dQ2
000145724 593__ $$aMolecular Biology$$c2024$$dQ2
000145724 593__ $$aEndocrinology, Diabetes and Metabolism$$c2024$$dQ2
000145724 594__ $$a6.9$$b2024
000145724 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145724 700__ $$0(orcid)0000-0001-6883-8940$$aCasas-Deza, Diego$$uUniversidad de Zaragoza
000145724 700__ $$aBernal-Monterde, Vanesa$$uUniversidad de Zaragoza
000145724 700__ $$aRoyo-Esteban, Ana
000145724 700__ $$aGarcía-Sobreviela, Maria Pilar
000145724 700__ $$aCalmarza, Pilar
000145724 700__ $$0(orcid)0000-0002-1557-7545$$aMartinez-Martinez, Ana B.$$uUniversidad de Zaragoza
000145724 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesús$$uUniversidad de Zaragoza
000145724 700__ $$0(orcid)0000-0002-8982-3737$$aArbones-Mainar, Jose M.
000145724 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000145724 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000145724 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000145724 773__ $$g14, 11 (2024), 618 [11 pp.]$$tMetabolites$$x2218-1989
000145724 8564_ $$s929633$$uhttps://zaguan.unizar.es/record/145724/files/texto_completo.pdf$$yVersión publicada
000145724 8564_ $$s2656551$$uhttps://zaguan.unizar.es/record/145724/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145724 909CO $$ooai:zaguan.unizar.es:145724$$particulos$$pdriver
000145724 951__ $$a2026-01-12-13:20:11
000145724 980__ $$aARTICLE