000145739 001__ 145739
000145739 005__ 20241122130824.0
000145739 0247_ $$2doi$$a10.3390/genes15111477
000145739 0248_ $$2sideral$$a140645
000145739 037__ $$aART-2024-140645
000145739 041__ $$aeng
000145739 100__ $$aHervás-Rivero, C.$$uUniversidad de Zaragoza
000145739 245__ $$aRuns of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
000145739 260__ $$c2024
000145739 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145739 5203_ $$aBackground/Objectives: Understanding the genetic architecture of autochthonous European cattle breeds is important for developing effective conservation strategies and sustainable breeding programs. Spanish beef cattle, which trace their origins to ancient migrations from the Near East with later admixture from African populations, exhibit a rich genetic diversity shaped by environmental adaptation and selective breeding. Runs of Homozygosity (ROH) are extended stretches of identical genetic material inherited from both parents. They serve as indicators of inbreeding and selection signatures within populations. ROH islands, or regions of the genome where ROH segments are highly concentrated across individuals within a breed, indicate genomic regions under selective pressure. Methods: This study explores the distribution of ROH islands across seven Spanish beef cattle breeds (Asturiana de los Valles, Avileña-Negra Ibérica, Bruna dels Pirineus, Morucha, Retinta, Pirenaica, and Rubia Gallega). By analyzing high-density SNP data, we characterized ROH patterns and identified genomic regions with high levels of homozygosity, which may indicate selection pressures or common ancestry. Results: Our findings revealed breed-specific ROH patterns as well as shared ROH islands, underscoring genetic relationships and differentiation among the breeds. Notably, Morucha displayed the highest number of ROH, while Asturiana de los Valles had the fewest. FROH values, which indicate genomic inbreeding, varied among the breeds, with Morucha and Retinta being associated with higher values. We identified 57 ROH islands, with shared regions among populations that suggest common ancestral selection pressures. Key genes within these regions, like MSTN, are associated with muscle growth, body weight, and fertility. Conclusions: This study offers valuable insights for breeding strategies and conservation efforts, highlighting the genetic diversity and historical background of Spanish cattle breeds.
000145739 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/AGL2010-15903
000145739 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000145739 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145739 700__ $$aMejuto-Vázquez, N.
000145739 700__ $$aLópez-Carbonell, D.$$uUniversidad de Zaragoza
000145739 700__ $$0(orcid)0000-0002-3042-2250$$aAltarriba, J.$$uUniversidad de Zaragoza
000145739 700__ $$aDiaz, C.
000145739 700__ $$aMolina, A.
000145739 700__ $$aRodríguez-Bermúdez, R.
000145739 700__ $$aPiedrafita, J.
000145739 700__ $$aBaro, J. A.
000145739 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, L.$$uUniversidad de Zaragoza
000145739 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000145739 773__ $$g15, 11 (2024), 1477 [12 pp.]$$pGenes (Basel)$$tGenes$$x2073-4425
000145739 8564_ $$s794062$$uhttps://zaguan.unizar.es/record/145739/files/texto_completo.pdf$$yVersión publicada
000145739 8564_ $$s2618909$$uhttps://zaguan.unizar.es/record/145739/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145739 909CO $$ooai:zaguan.unizar.es:145739$$particulos$$pdriver
000145739 951__ $$a2024-11-22-11:53:36
000145739 980__ $$aARTICLE