000146900 001__ 146900
000146900 005__ 20241129141114.0
000146900 0247_ $$2doi$$a10.1016/j.clnu.2024.10.022
000146900 0248_ $$2sideral$$a140706
000146900 037__ $$aART-2024-140706
000146900 041__ $$aeng
000146900 100__ $$aPolo-López, Ana
000146900 245__ $$aJoint associations of handgrip strength and physical activity with incident cardiovascular disease and overall mortality in the UK Biobank
000146900 260__ $$c2024
000146900 5060_ $$aAccess copy available to the general public$$fUnrestricted
000146900 5203_ $$aBackground & aims
Questions remain whether higher handgrip strength confers additional health advantages beyond adherence to current physical activity guidelines. We aimed to evaluate prospective associations of joint objectively measured handgrip strength and physical activity with incident cardiovascular disease (CVD) and all-cause mortality.
Methods
We analysed the UK Biobank study in a cohort of participants who wore accelerometers for one week, with follow-up based on hospital records until 2022. Patterns of physical activity were compared: participants who met current moderate-vigorous physical activity guidelines (150 min per week) and those who did not. Handgrip strength was classified into sex- and age-specific tertiles. CVD events were identified as primary or secondary by examination of inpatient records and data extracted from the death registry. CVD-related deaths were also identified from the death registry. We examined prospective associations of moderate-vigorous physical activity with incident CVD and all-cause mortality by level of handgrip using Cox regressions, adjusted for confounding factors.
Results
A total of 76 074 persons were included (mean 55.2 years). Meeting physical activity guidelines is necessary to reduce all-cause mortality in those at the lower and middle thirds of handgrip strength. However, meeting physical activity guidelines did not confer additional reduction of all-cause mortality of those with high handgrip strength. Those with the lowest handgrip strength showed the greatest benefit from meeting physical activity guidelines for reducing all-cause mortality (HR 0.74; 95 % CI 0.65–0.85).
Conclusion
Our results indicate that, while following physical activity guidelines does not reduce mortality in individuals with high handgrip strength, it is essential for preventing cardiovascular disease across all levels of handgrip strength. This underscores the importance of these guidelines for cardiovascular health.
000146900 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000146900 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000146900 700__ $$aCalatayud, Joaquín
000146900 700__ $$aPalau, Patricia
000146900 700__ $$aLópez-Bueno, Laura
000146900 700__ $$aNúñez-Cortés, Rodrigo
000146900 700__ $$aAndersen, Lars Louis
000146900 700__ $$0(orcid)0000-0002-7865-3429$$aLópez-Bueno, Rubén$$uUniversidad de Zaragoza
000146900 7102_ $$13001$$2187$$aUniversidad de Zaragoza$$bDpto. Expres.Music.Plást.Corp.$$cÁrea Didáctica Expres.Corporal
000146900 773__ $$g43, 12 (2024), 218-224$$pClin. nutr.$$tClinical Nutrition$$x0261-5614
000146900 8564_ $$s622566$$uhttps://zaguan.unizar.es/record/146900/files/texto_completo.pdf$$yVersión publicada
000146900 8564_ $$s2404509$$uhttps://zaguan.unizar.es/record/146900/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000146900 909CO $$ooai:zaguan.unizar.es:146900$$particulos$$pdriver
000146900 951__ $$a2024-11-29-13:24:02
000146900 980__ $$aARTICLE