Resumen: Substance use/abuse and suicide are two closely related phenomena, mostly due to neurobiological, psychological, and social impairments. In the present narrative review, the relationship between suicidal behavior (SB) and the use and abuse of common recreational drugs, such as alcohol, cannabis, cocaine, methamphetamine, heroin, nicotine, ketamine, psilocybin, MDMA, and LSD, has been explored. Furthermore, potential mechanisms linking the two have also been examined. According to current research, all substances appear to have a deleterious effect on SB except for ketamine and psilocybin, which could potentially confer a protective effect. Further studies are needed to understand the relationship between MDMA, LSD, and suicide. Idioma: Inglés DOI: 10.3390/psychoactives3030021 Año: 2024 Publicado en: Psychoactives 3, 3 (2024), 337-356 ISSN: 2813-1851 Tipo y forma: Revisión (Versión definitiva) Área (Departamento): Área Person.Eval.Trat.Psicoló. (Dpto. Psicología y Sociología)