000146953 001__ 146953
000146953 005__ 20241129141115.0
000146953 0247_ $$2doi$$a10.3390/jcm13133979
000146953 0248_ $$2sideral$$a140698
000146953 037__ $$aART-2024-140698
000146953 041__ $$aeng
000146953 100__ $$0(orcid)0000-0001-7136-2189$$aGracia Gutiérrez, Anyuli$$uUniversidad de Zaragoza
000146953 245__ $$aMultimorbidity in Incident Heart Failure: Characterisation and Impact on 1-Year Outcomes
000146953 260__ $$c2024
000146953 5060_ $$aAccess copy available to the general public$$fUnrestricted
000146953 5203_ $$aBackground/Objectives: Heart failure (HF) is usually accompanied by other comorbidities, which, altogether, have a major impact on patients and healthcare systems. Our aim was to analyse the demographic and clinical characteristics of incident HF patients and the effect of comorbidities on one-year health outcomes. Methods: This was an observational, retrospective, population-based study of incident HF patients between 2014 and 2018 in the EpiChron Cohort, Spain. The included population contained all primary and hospital care patients with a diagnosis of HF. All chronic diseases in their electronic health records were pooled into three comorbidity clusters (cardiovascular, mental, other physical). These comorbidity groups and the health outcomes were analysed until 31 December 2018. A descriptive analysis was performed. Cox regression models and survival curves were calculated to determine the hazard risk (HR) of all-cause mortality, all-cause and HF-related hospital admissions, hospital readmissions, and emergency room visits for each comorbidity group. Results: In total, 13,062 incident HF patients were identified (mean age = 82.0 years; 54.8% women; 93.7% multimorbid; mean of 4.52 ± 2.06 chronic diseases). After one-year follow-up, there were 3316 deaths (25.3%) and 4630 all-cause hospitalisations (35.4%). After adjusting by gender, age, and inpatient/outpatient status, the mental cluster was associated (HR; 95% confidence interval) with a higher HR of death (1.08; 1.01–1.16) and all-cause hospitalisation (1.09; 1.02–1.16). Conclusions: Cardiovascular comorbidities are the most common and studied ones in HF patients; however, they are not the most strongly associated with negative impacts on health outcomes in these patients. Our findings suggest the importance of a holistic and integral approach in the care of HF patients and the need to take into account the entire spectrum of comorbidities for improving HF management in clinical practice.
000146953 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B01-23R
000146953 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000146953 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000146953 700__ $$aMoreno-Juste, Aida
000146953 700__ $$aLaguna-Berna, Clara
000146953 700__ $$aSantos-Mejías, Alejandro
000146953 700__ $$0(orcid)0000-0002-5119-5093$$aPoblador-Plou, Beatriz
000146953 700__ $$0(orcid)0000-0002-5440-1710$$aGimeno-Miguel, Antonio
000146953 700__ $$0(orcid)0000-0002-5172-0388$$aRuiz Laiglesia, Fernando J.$$uUniversidad de Zaragoza
000146953 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000146953 773__ $$g13, 13 (2024), 3979 [11 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000146953 8564_ $$s2947304$$uhttps://zaguan.unizar.es/record/146953/files/texto_completo.pdf$$yVersión publicada
000146953 8564_ $$s2467527$$uhttps://zaguan.unizar.es/record/146953/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000146953 909CO $$ooai:zaguan.unizar.es:146953$$particulos$$pdriver
000146953 951__ $$a2024-11-29-13:24:56
000146953 980__ $$aARTICLE