000147048 001__ 147048
000147048 005__ 20250115151522.0
000147048 0247_ $$2doi$$a10.1016/j.rceng.2024.07.006
000147048 0248_ $$2sideral$$a140810
000147048 037__ $$aART-2024-140810
000147048 041__ $$aeng
000147048 100__ $$aRuiz Hueso, R.
000147048 245__ $$aCardiac amyloidosis worsens prognosis in patients with heart failure: findings from the PREVAMIC study
000147048 260__ $$c2024
000147048 5203_ $$aBackground and objectives
Cardiac amyloidosis (CA) is a common pathology in elderly patients that usually presents as heart failure (HF). However, it is not clear whether CA associated with HF has a worse prognosis compared with HF due to other etiologies.
Material and methods
Prospective, observational cohort study that recruited patients ≥65 years of age with HF in 30 Spanish centers. The cohort was divided according to whether the patients had AC or not. Patients were followed for 1 year.
Results
A total of 484 patients were included in the analysis. The population was elderly (median 86 years) and 49% were women CA was present in 23.8 % of the included patients. In the CA group, there was a lower prevalence of diabetes mellitus and valvular disease. At one year of follow-up, mortality was significantly more frequent in patients with CA compared to those without (33.0 vs.14.9%, p < 0.001). However, there were no differences between both groups in visits to the emergency room or readmissions. In the multivariate analysis, the variables that were shown to predict all-cause mortality at one year of follow-up were chronic kidney disease (HR 1.75 (1.01–3.05) p 0.045), NT-proBNP levels (HR 2.51 (1.46–4.30) p < 0.001), confusion (HR 2.05 (1.01–4.17), p 0.048), and the presence of CA (HR 1.77 (1.11–2.84), p 0.017).
Conclusion
The presence of CA in elderly patients with HF is related to a worse prognosis at one year of follow-up. Early diagnosis of the pathology and multidisciplinary management can help improve patient outcomes.
000147048 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000147048 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147048 700__ $$aSalamanca Bautista, P.
000147048 700__ $$aQuesada Simón, M.A.
000147048 700__ $$aYun, S.
000147048 700__ $$aConde Martel, A.
000147048 700__ $$aMorales Rull, J.L.
000147048 700__ $$aFiteni Mera, I.
000147048 700__ $$aAbad Pérez, D.
000147048 700__ $$aPáez Rubio, I.
000147048 700__ $$aAramburu Bodas, Ó.
000147048 700__ $$aAbad Pérez, D.
000147048 700__ $$0(orcid)0000-0001-6613-0359$$aAmores Arriaga, B.$$uUniversidad de Zaragoza
000147048 700__ $$aAmorós Martínez, F.
000147048 700__ $$aAndrés Imaz, N.
000147048 700__ $$aAramburu Bodas, O.
000147048 700__ $$aArmengou Arxe, A.
000147048 700__ $$aBermudo Guitarte, C.
000147048 700__ $$aBernardo Galán, P.
000147048 700__ $$aBonache Bernal, F.
000147048 700__ $$aCalero Molina, E.
000147048 700__ $$aCalvo Morón, M.C.
000147048 700__ $$aCasado Cerrada, J.
000147048 700__ $$aCastillo Paredes, M.
000147048 700__ $$aCepeda Rodrigo, J.M.
000147048 700__ $$aChoucino Fernández, T.
000147048 700__ $$aConde Martel, A.
000147048 700__ $$aCuadrat Begue, I.
000147048 700__ $$aDelgado Verges, C.
000147048 700__ $$0(orcid)0000-0002-3132-2171$$aDíez Manglano, J.$$uUniversidad de Zaragoza
000147048 700__ $$aDomingo Baldrich, E.
000147048 700__ $$aFernández Soler, C.
000147048 700__ $$aFiteni Mera, I.
000147048 700__ $$aFonseca Aizpuru, E.M.
000147048 700__ $$aFormiga, F.
000147048 700__ $$aGarcía García, J.A.
000147048 700__ $$aGarcía-Fernández Bravo, I.
000147048 700__ $$aGonzález Moraleja, J.
000147048 700__ $$aLiroa Romero, M.F.
000147048 700__ $$aLlàcer Iborra, P.
000147048 700__ $$aLópez Reboiro, M.L.
000147048 700__ $$aMartínez González, A.
000147048 700__ $$aMartínez Rodés, P.
000147048 700__ $$aMéndez Bailón, M.
000147048 700__ $$aMontero Hernández, E.
000147048 700__ $$aMorales Rull, J.L.
000147048 700__ $$aMoya Saiz, M.J.
000147048 700__ $$aMuela Molinero, A.
000147048 700__ $$aNavarro Sáez, M.C.
000147048 700__ $$aPacheco Castellanos, M.C.
000147048 700__ $$aPáez Rubio, I.
000147048 700__ $$aPeña Somovilla, J.L.
000147048 700__ $$aPérez Bocanegra, C.
000147048 700__ $$aQuesada Simón, M.A.
000147048 700__ $$aRedondo Galán, M.P.
000147048 700__ $$aRuiz Hueso, R.
000147048 700__ $$aSalamanca Bautista, P.
000147048 700__ $$aSánchez Castaño, A.J.
000147048 700__ $$aSeoane González, B.
000147048 700__ $$aSoler Rangel, M.L.
000147048 700__ $$aSoriano Sánchez, T.
000147048 700__ $$aSuárez Gil, R.
000147048 700__ $$aVaquero Hernández, J.M.
000147048 700__ $$aVicente Rodrigo, J.A.
000147048 700__ $$aYun, S.
000147048 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000147048 773__ $$g224, 8 (2024), 494-502$$tRevista Clínica Española (English Edition)$$x2254-8874
000147048 8564_ $$s809847$$uhttps://zaguan.unizar.es/record/147048/files/texto_completo.pdf$$yVersión publicada
000147048 8564_ $$s1920341$$uhttps://zaguan.unizar.es/record/147048/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147048 909CO $$ooai:zaguan.unizar.es:147048$$particulos$$pdriver
000147048 951__ $$a2025-01-15-15:14:42
000147048 980__ $$aARTICLE