147114 20260217205534.0 doi 10.1038/s41541-024-01009-5 sideral 140970 ART-2024-140970 eng Peralta-Álvarez, Marco Polo MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates 2024 Access copy available to the general public Unrestricted The only currently licensed vaccine against tuberculosis (TB), Bacille Calmette Guérin (BCG), is insufficient to control the epidemic. MTBVAC is a live attenuated strain of Mycobacterium tuberculosis (M.tb) and is one the most advanced TB vaccine candidates in the pipeline. It is more efficacious than BCG in preclinical models including non-human primates (NHPs), and has demonstrated safety and immunogenicity in human populations. To better understand the immune mechanisms underlying the superior efficacy conferred by MTBVAC, we characterized M.tb-specific antibody responses in NHPs vaccinated with either BCG or MTBVAC. MTBVAC vaccination induced higher titers of IgG, IgM and IgA, and higher avidity IgG compared with BCG vaccination. IgG avidity correlated with protection following M.tb challenge in the same animals, validating the association previously reported between this measure and protection in the context of intravenous BCG vaccination, suggesting that IgG avidity may represent a relevant marker or correlate of protection from TB. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 6.6 2024 MEDICINE, RESEARCH & EXPERIMENTAL 30 / 195 = 0.154 2024 Q1 T1 IMMUNOLOGY 28 / 183 = 0.153 2024 Q1 T1 2.236 2024 Immunology 2024 Q1 Pharmacology (medical) 2024 Q1 Pharmacology 2024 Q1 Infectious Diseases 2024 Q1 11.6 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Downward, Keya White, Andrew Redondo Azema, Hugo Sibley, Laura Sarfas, Charlotte Morrison, Alexandra Dennis, Mike Diaz-Santana, Delia Harris, Stephanie A. Li, Shuailin Puentes, Eugenia Aguilo, Nacho Universidad de Zaragoza (orcid)0000-0001-7897-9173 Martin, Carlos Universidad de Zaragoza (orcid)0000-0003-2993-5478 Sharpe, Sally McShane, Helen Tanner, Rachel 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 9, 1 (2024), 10 pp. npj Vaccines npj Vaccines 2059-0105 1774531 http://zaguan.unizar.es/record/147114/files/texto_completo.pdf Versión publicada 2903724 http://zaguan.unizar.es/record/147114/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:147114 articulos driver 2026-02-17-20:33:46 ARTICLE