147140 20260217205539.0 doi 10.1088/1741-2552/ad8835 sideral 140906 ART-2024-140906 eng Zicher, Blanka Changes in high-frequency neural inputs to muscles during movement cancellation 2024 Access copy available to the general public Unrestricted Objective. Cortical beta (13–30 Hz) and gamma (30–60 Hz) oscillations are prominent in the motor cortex and are known to be transmitted to the muscles despite their limited direct impact on force modulation. However, we currently lack fundamental knowledge about the saliency of these oscillations at spinal level. Here, we developed an experimental approach to examine the modulations in high-frequency inputs to motoneurons under different motor states while maintaining a stable force, thus constraining behaviour. Approach. Specifically, we acquired brain and muscle activity during a ‘GO’/’NO-GO’ task. In this experiment, the effector muscle for the task (tibialis anterior) was kept tonically active during the trials, while participants (N = 12) reacted to sequences of auditory stimuli by either keeping the contraction unaltered (‘NO-GO’ trials), or by quickly performing a ballistic contraction (‘GO’ trials). Motor unit (MU) firing activity was extracted from high-density surface and intramuscular electromyographic signals, and the changes in its spectral contents in the ‘NO-GO’ trials were analysed. Main results. We observed an increase in beta and low-gamma (30–45 Hz) activity after the ‘NO-GO’ cue in the MU population activity. These results were in line with the brain activity changes measured with electroencephalography. These increases in power occur without relevant alterations in force, as behaviour was restricted to a stable force contraction. Significance. We show that modulations in motor cortical beta and gamma rhythms are also present in muscles when subjects cancel a prepared ballistic action while holding a stable contraction in a ‘GO’/’NO-GO’ task. This occurs while force levels produced by the task effector muscle remain largely unaltered. Our results suggest that muscle recordings are informative also about motor states that are not force-control signals. This opens up new potential use cases of peripheral neural interfaces. info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101077693/EU/Extracting the Human Motor Null Space from Muscles - A new framework to measure human neural activity/ECHOES info:eu-repo/grantAgreement/EC/H2020/810346/EU/Natural Integration of Bionic Limbs via Spinal Interfacing/Natural BionicS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 810346-Natural BionicS info:eu-repo/grantAgreement/EC/H2020/899626/EU/NIMA: Non-invasive Interface for Movement Augmentation/NIMA This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 899626-NIMA info:eu-repo/grantAgreement/ES/MICINN/RYC2021-031905-I info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.8 2024 NEUROSCIENCES 95 / 314 = 0.303 2024 Q2 T1 ENGINEERING, BIOMEDICAL 48 / 124 = 0.387 2024 Q2 T2 1.127 2024 Biomedical Engineering 2024 Q1 Cellular and Molecular Neuroscience 2024 Q2 7.8 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avrillon, Simon Ibáñez, Jaime Universidad de Zaragoza (orcid)0000-0001-8439-151X Farina, Dario 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 21, 5 (2024), 056039 [12 pp.] J. neural eng. Journal of Neural Engineering 1741-2560 2220349 http://zaguan.unizar.es/record/147140/files/texto_completo.pdf Versión publicada 1426977 http://zaguan.unizar.es/record/147140/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:147140 articulos driver 2026-02-17-20:35:35 ARTICLE