Repositorio Institucional de Documentos

000147262 001__ 147262
000147262 005__ 20250923084437.0
000147262 0247_ $$2doi$$a10.1183/23120541.00341-2024
000147262 0248_ $$2sideral$$a141078
000147262 037__ $$aART-2024-141078
000147262 041__ $$aeng
000147262 100__ $$aSillanmäki, Saara
000147262 245__ $$aHypoxaemic load in sleep apnoea is associated with acute changes in T-wave amplitude
000147262 260__ $$c2024
000147262 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147262 5203_ $$aAimsObstructive sleep apnoea (OSA) imposes significant stress on the cardiovascular system and the heart. While long-term cardiac effects are understood, the immediate impact of hypoxaemia on the heart's electrophysiology lacks understanding. Our study aims to explore desaturation severity on cardiovascular repolarisation.MethodsWe retrospectively analysed ECGs from full diagnostic polysomnographies from 492 patients with suspected OSA. The analyses were conducted before, during and after 9137 nocturnal apnoea- or hypopnoea-related desaturations. The mean andsdof T-wave amplitude change from the baseline level to the level during and after desaturations (ΔTamp_meanand ΔTamp_SD) were calculated. To investigate the modulatory effects of desaturation severity, the data were divided into subgroups based on the desaturation duration (Tdes; 10 s≤Tdes<20 s, 20 s≤Tdes<30 s, 30 s≤Tdes<45 s and Tdes≥45 s) and magnitude of blood oxygen saturation drop (change in peripheral oxygen saturation (ΔSpO2); 3%≤ΔSpO2<4.5%, 4.5%≤ΔSpO2<6%, 6%≤ΔSpO2<7.5% and ΔSpO2≥7.5%) for men and women.ResultsDesaturations caused significant (p<0.01) changes in ΔTamp_meanduring and after desaturations. In men, the median ΔTamp_meanduring and after deep (ΔSpO2≥7.5%) desaturations were 21 µV and 24 µV, respectively. In women, the median ΔTamp_meanin deep desaturations was 15 µV during and 21 µV after desaturations. Similarly, the ΔTamp_SDincreased during and after deep desaturations. In regression analysis, the desaturation depth was an independent predictor for ventricular repolarisation instability.ConclusionWe found an association between the severity of nocturnal desaturations and cardiac repolarisation instability. These findings hold particular importance, as repolarisation instability has been linked with cardiovascular morbidity and could potentially serve as a trigger for arrhythmias and sudden cardiac death.
000147262 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group$$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-126734OB-C21
000147262 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000147262 590__ $$a4.0$$b2024
000147262 592__ $$a1.367$$b2024
000147262 591__ $$aRESPIRATORY SYSTEM$$b21 / 108 = 0.194$$c2024$$dQ1$$eT1
000147262 593__ $$aPulmonary and Respiratory Medicine$$c2024$$dQ1
000147262 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147262 700__ $$aEbrahimian, Serajeddin
000147262 700__ $$aHietakoste, Salla
000147262 700__ $$0(orcid)0000-0002-1462-4880$$aHernando, David
000147262 700__ $$0(orcid)0000-0003-1272-0550$$aBailon, Raquel$$uUniversidad de Zaragoza
000147262 700__ $$aLeppänen, Timo
000147262 700__ $$aKainulainen, Samu
000147262 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000147262 773__ $$g10, 5 (2024), 00341-2024$$pERJ open res.$$tERJ Open Research$$x2312-0541
000147262 8564_ $$s614266$$uhttps://zaguan.unizar.es/record/147262/files/texto_completo.pdf$$yVersión publicada
000147262 8564_ $$s2694698$$uhttps://zaguan.unizar.es/record/147262/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147262 909CO $$ooai:zaguan.unizar.es:147262$$particulos$$pdriver
000147262 951__ $$a2025-09-22-14:47:33
000147262 980__ $$aARTICLE

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