147262 20260217205607.0 doi 10.1183/23120541.00341-2024 sideral 141078 ART-2024-141078 eng Sillanmäki, Saara Hypoxaemic load in sleep apnoea is associated with acute changes in T-wave amplitude 2024 Access copy available to the general public Unrestricted AimsObstructive sleep apnoea (OSA) imposes significant stress on the cardiovascular system and the heart. While long-term cardiac effects are understood, the immediate impact of hypoxaemia on the heart's electrophysiology lacks understanding. Our study aims to explore desaturation severity on cardiovascular repolarisation.MethodsWe retrospectively analysed ECGs from full diagnostic polysomnographies from 492 patients with suspected OSA. The analyses were conducted before, during and after 9137 nocturnal apnoea- or hypopnoea-related desaturations. The mean andsdof T-wave amplitude change from the baseline level to the level during and after desaturations (ΔTamp_meanand ΔTamp_SD) were calculated. To investigate the modulatory effects of desaturation severity, the data were divided into subgroups based on the desaturation duration (Tdes; 10 s≤Tdes<20 s, 20 s≤Tdes<30 s, 30 s≤Tdes<45 s and Tdes≥45 s) and magnitude of blood oxygen saturation drop (change in peripheral oxygen saturation (ΔSpO2); 3%≤ΔSpO2<4.5%, 4.5%≤ΔSpO2<6%, 6%≤ΔSpO2<7.5% and ΔSpO2≥7.5%) for men and women.ResultsDesaturations caused significant (p<0.01) changes in ΔTamp_meanduring and after desaturations. In men, the median ΔTamp_meanduring and after deep (ΔSpO2≥7.5%) desaturations were 21 µV and 24 µV, respectively. In women, the median ΔTamp_meanin deep desaturations was 15 µV during and 21 µV after desaturations. Similarly, the ΔTamp_SDincreased during and after deep desaturations. In regression analysis, the desaturation depth was an independent predictor for ventricular repolarisation instability.ConclusionWe found an association between the severity of nocturnal desaturations and cardiac repolarisation instability. These findings hold particular importance, as repolarisation instability has been linked with cardiovascular morbidity and could potentially serve as a trigger for arrhythmias and sudden cardiac death. info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-126734OB-C21 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 4.0 2024 RESPIRATORY SYSTEM 21 / 108 = 0.194 2024 Q1 T1 1.367 2024 Pulmonary and Respiratory Medicine 2024 Q1 6.6 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ebrahimian, Serajeddin Hietakoste, Salla Hernando, David (orcid)0000-0002-1462-4880 Bailon, Raquel Universidad de Zaragoza (orcid)0000-0003-1272-0550 Leppänen, Timo Kainulainen, Samu 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 10, 5 (2024), 00341-2024 ERJ open res. ERJ Open Research 2312-0541 614266 http://zaguan.unizar.es/record/147262/files/texto_completo.pdf Versión publicada 2694698 http://zaguan.unizar.es/record/147262/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:147262 articulos driver 2026-02-17-20:47:18 ARTICLE