000147635 001__ 147635
000147635 005__ 20250923084413.0
000147635 0247_ $$2doi$$a10.1108/COMPEL-09-2023-0418
000147635 0248_ $$2sideral$$a137499
000147635 037__ $$aART-2024-137499
000147635 041__ $$aeng
000147635 100__ $$0(orcid)0000-0003-2848-170X$$aLópez-Alonso, Borja$$uUniversidad de Zaragoza
000147635 245__ $$aOptimizing IRE targeting using multi-electrode structure and biomedical multi-output generator
000147635 260__ $$c2024
000147635 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147635 5203_ $$aPurpose
This paper aims to study the feasibility of proposed method to focus the electroporation ablation by mean of multi-output multi-electrode system.
Design/methodology/approach
The proposed method has been developed based on a previously designed electroporation system, which has the capabilities to modify the electric field distribution in real time, and to estimate the impedance distribution. Taking into consideration the features of the system and biological tissues, the problem has been addressed in three phases: modeling, control system design and simulation testing. In the first phase, a finite element analysis model has been proposed to reproduce the electric field distribution within the hepatic tissue, based on the characteristics of the electroporation system. Then, a control strategy has been proposed with the goal of ensuring complete ablation while minimizing the affected volume of healthy tissue. Finally, to check the feasibility of the proposal, several representative cases have been simulated, and the results have been compared with those obtained by a traditional system.
Findings
The proposed method achieves the proposed goal, as part of a complex electroporation system designed to improve the targeting, effectiveness and control of electroporation treatments and serve to demonstrate the feasibility of developing new electroporation systems capable of adapting to changes in the preplanning of the treatment in real-time.
Originality/value
The work presents a thorough study of control method to multi-output multi-electrode electroporation system by mean of a rigorous numerical simulation.
000147635 536__ $$9info:eu-repo/grantAgreement/EUR/AEI/TED2021-129274B-I00$$9info:eu-repo/grantAgreement/ES/ISCIII/PI21-00440$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PDC2021-120898-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-136621OB-I00
000147635 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000147635 590__ $$a1.0$$b2024
000147635 592__ $$a0.324$$b2024
000147635 591__ $$aMATHEMATICS, APPLIED$$b192 / 343 = 0.56$$c2024$$dQ3$$eT2
000147635 591__ $$aCOMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS$$b150 / 175 = 0.857$$c2024$$dQ4$$eT3
000147635 591__ $$aENGINEERING, ELECTRICAL & ELECTRONIC$$b303 / 366 = 0.828$$c2024$$dQ4$$eT3
000147635 593__ $$aApplied Mathematics$$c2024$$dQ3
000147635 593__ $$aComputer Science Applications$$c2024$$dQ3
000147635 593__ $$aComputational Theory and Mathematics$$c2024$$dQ3
000147635 593__ $$aElectrical and Electronic Engineering$$c2024$$dQ3
000147635 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000147635 700__ $$0(orcid)0000-0002-6768-5177$$aBriz, Pablo$$uUniversidad de Zaragoza
000147635 700__ $$0(orcid)0000-0001-8399-4650$$aSarnago, Hector$$uUniversidad de Zaragoza
000147635 700__ $$0(orcid)0000-0002-9655-5531$$aBurdio, José M.$$uUniversidad de Zaragoza
000147635 700__ $$0(orcid)0000-0002-1284-9007$$aLucia, Oscar$$uUniversidad de Zaragoza
000147635 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica
000147635 773__ $$g43, 6 (2024), 1184-1196$$pCompel$$tCOMPEL-THE INTERNATIONAL JOURNAL FOR COMPUTATION AND MATHEMATICS IN ELECTRICAL AND ELECTRONIC ENGINEERING$$x0332-1649
000147635 8564_ $$s580245$$uhttps://zaguan.unizar.es/record/147635/files/texto_completo.pdf$$yPostprint
000147635 8564_ $$s2355019$$uhttps://zaguan.unizar.es/record/147635/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000147635 909CO $$ooai:zaguan.unizar.es:147635$$particulos$$pdriver
000147635 951__ $$a2025-09-22-14:31:31
000147635 980__ $$aARTICLE