000147665 001__ 147665
000147665 005__ 20260112133315.0
000147665 0247_ $$2doi$$a10.1063/5.0230834
000147665 0248_ $$2sideral$$a141139
000147665 037__ $$aART-2024-141139
000147665 041__ $$aeng
000147665 100__ $$aKitajima, Hiroyuki
000147665 245__ $$aFast–slow analysis and bifurcations in the generation of the early afterdepolarization phenomenon in a realistic mathematical human ventricular myocyte model
000147665 260__ $$c2024
000147665 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147665 5203_ $$aEarly afterdepolarizations (EADs) are spontaneous oscillations in membrane potential that occur during the repolarization phase of the action potential. EADs can trigger ventricular arrhythmias, such as Torsades de Pointes, in patients with long QT syndromes. Understanding the theoretical mechanisms behind EAD generation and developing strategies to suppress them are crucial. In this study, we employed bifurcation analysis along with a new fast–slow decomposition method on the O’Hara model of human ventricular myocytes. Our goal was to examine how the calcium ion concentration in the network sarcoplasmic reticulum (NSR) influences the generation of EADs in the context of reduced rapid delayed rectifier K+ current. Our findings identified nine distinct EAD states that coexist and can be controlled by slight adjustments to the NSR calcium ion concentration at a single time point.
000147665 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-122961NB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E24-23R$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00
000147665 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000147665 590__ $$a3.2$$b2024
000147665 592__ $$a0.77$$b2024
000147665 591__ $$aPHYSICS, MATHEMATICAL$$b5 / 61 = 0.082$$c2024$$dQ1$$eT1
000147665 593__ $$aPhysics and Astronomy (miscellaneous)$$c2024$$dQ1
000147665 591__ $$aMATHEMATICS, APPLIED$$b13 / 343 = 0.038$$c2024$$dQ1$$eT1
000147665 593__ $$aMathematical Physics$$c2024$$dQ2
000147665 593__ $$aStatistical and Nonlinear Physics$$c2024$$dQ2
000147665 593__ $$aApplied Mathematics$$c2024$$dQ2
000147665 593__ $$aMedicine (miscellaneous)$$c2024$$dQ2
000147665 594__ $$a4.8$$b2024
000147665 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000147665 700__ $$aYazawa, Toru
000147665 700__ $$0(orcid)0000-0002-8089-343X$$aBarrio, Roberto$$uUniversidad de Zaragoza
000147665 7102_ $$12005$$2595$$aUniversidad de Zaragoza$$bDpto. Matemática Aplicada$$cÁrea Matemática Aplicada
000147665 773__ $$g34, 12 (2024), 13 pp.$$pChaos$$tCHAOS$$x1054-1500
000147665 8564_ $$s3537271$$uhttps://zaguan.unizar.es/record/147665/files/texto_completo.pdf$$yPostprint
000147665 8564_ $$s3256658$$uhttps://zaguan.unizar.es/record/147665/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000147665 909CO $$ooai:zaguan.unizar.es:147665$$particulos$$pdriver
000147665 951__ $$a2026-01-12-13:03:56
000147665 980__ $$aARTICLE