000147684 001__ 147684
000147684 005__ 20241220131257.0
000147684 0247_ $$2doi$$a10.1016/j.csfx.2024.100122
000147684 0248_ $$2sideral$$a141100
000147684 037__ $$aART-2024-141100
000147684 041__ $$aeng
000147684 100__ $$0(orcid)0000-0001-6859-099X$$aFiasconaro, Alessandro$$uUniversidad de Zaragoza
000147684 245__ $$aEffects of synapse location, delay and background stochastic activity on synchronising hippocampal CA1 neurons
000147684 260__ $$c2024
000147684 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147684 5203_ $$aWe study the synchronisation of neurons in a realistic model under the Hodgkin–Huxley dynamics. To focus on the role of the different locations of the excitatory synapses, we use two identical neurons where the set of input signals is grouped at two different distances from the soma. The system is intended to represent a CA1 hippocampal neuron in which the synapses arriving from the CA3 neurons of the trisynaptic pathway appear to be localised in the apical dendritic region and are, in principle, either proximal or distal to the soma. Synchronisation is studied using a specifically defined spiking correlation function as a function of various parameters such as the distance from the soma of one of the synaptic groups, the inhibition weight and the associated activation delay. We found that the neurons’ spiking activity depends nonmonotonically on the relative dendritic location of the synapses and their inhibition weight, while the synchronisation measure always decreases with inhibition, and strongly depends on its activation time delay. In our model, the synaptic random subthreshold background activity substantially reduces synchronisation in a monotonic way, while highlights the importance of a balanced E/I contribution for neuronal synchronisation.
000147684 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E36-23R-FENOL$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113582GB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2023-147734NB-I00
000147684 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000147684 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147684 700__ $$aMigliore, Michele
000147684 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000147684 773__ $$g13 (2024), 100122 [8 p.]$$tChaos, Solitons and Fractals: X$$x2590-0544
000147684 8564_ $$s1775439$$uhttps://zaguan.unizar.es/record/147684/files/texto_completo.pdf$$yVersión publicada
000147684 8564_ $$s2692042$$uhttps://zaguan.unizar.es/record/147684/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147684 909CO $$ooai:zaguan.unizar.es:147684$$particulos$$pdriver
000147684 951__ $$a2024-12-20-12:01:52
000147684 980__ $$aARTICLE