000147724 001__ 147724
000147724 005__ 20250923084440.0
000147724 0247_ $$2doi$$a10.1186/s12917-024-04395-z
000147724 0248_ $$2sideral$$a141149
000147724 037__ $$aART-2024-141149
000147724 041__ $$aeng
000147724 100__ $$aEsmaeili, Hossein
000147724 245__ $$aLive attenuated goatpox vaccination in pregnant Murcia-Granada goats: dosage implications and outcomes
000147724 260__ $$c2024
000147724 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147724 5203_ $$aBackground
Infectious diseases, particularly the Goatpox virus (GTPV) from the Poxviridae family, significantly impact livestock health and agricultural economies, especially in developing regions. Recent GTPV outbreaks in previously eradicated areas underscore the need for effective control measures, with vaccination being the most reliable strategy. This study investigates the effects of administering standard and double doses of live attenuated goatpox vaccine in pregnant Murcia-Granada goats, a non-native breed in Iran, to determine optimal vaccination protocols.
Results
In 2018, 400 healthy and pregnant Murcia Granada goats imported from Spain were divided into groups of 200 and vaccinated with either a standard dose (0.5 ml) or a double dose (single 0.9 ml injection) of live attenuated goatpox vaccine. Post-vaccination, the goats were monitored daily for clinical signs of infection, with samples collected for PCR analysis to detect the presence of GTPV strains. In group A, which received the standard vaccine dose, no abortions or vaccine-related side effects were observed, and body temperatures remained normal. In group B, administered a double dose, 37% of the goats experienced abortions, displaying signs of GTPV infection, such as skin lesions (pox lesions) and increased body temperatures. Molecular analysis confirmed the vaccine strain of GTPV as the infection source, ruling out external contamination. Statistical analysis showed no significant differences in abortion rates concerning gestational age or t he age of the pregnant goats.
Conclusion
The study highlights the importance of adhering to standard vaccine dosages in pregnant Murcia Granada goats to prevent adverse outcomes like abortions. This study emphasizes the necessity to review and revise vaccination protocols tailored to specific breeds and varying maintenance conditions, including pregnancy and outbreak scenarios. These findings stress the necessity for cautious and tailored vaccination strategies to ensure the safety and efficacy of vaccines in different goat breeds.
000147724 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000147724 590__ $$a2.6$$b2024
000147724 592__ $$a0.723$$b2024
000147724 591__ $$aVETERINARY SCIENCES$$b23 / 170 = 0.135$$c2024$$dQ1$$eT1
000147724 593__ $$aVeterinary (miscellaneous)$$c2024$$dQ1
000147724 593__ $$aMedicine (miscellaneous)$$c2024$$dQ2
000147724 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147724 700__ $$aGhorani, Mohammadreza
000147724 700__ $$aJoghataei, Seyed Mehdi
000147724 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000147724 700__ $$0(orcid)0000-0002-7822-6646$$aLacasta, Delia$$uUniversidad de Zaragoza
000147724 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000147724 773__ $$g20 (2024), 544 [7 pp.]$$pBMC Vet. Res.$$tBMC VETERINARY RESEARCH$$x1746-6148
000147724 8564_ $$s1081635$$uhttps://zaguan.unizar.es/record/147724/files/texto_completo.pdf$$yVersión publicada
000147724 8564_ $$s2087403$$uhttps://zaguan.unizar.es/record/147724/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147724 909CO $$ooai:zaguan.unizar.es:147724$$particulos$$pdriver
000147724 951__ $$a2025-09-22-14:49:54
000147724 980__ $$aARTICLE