147753 20250103153613.0 doi 10.1098/rsif.2020.0341 sideral 119583 ART-2020-119583 eng Júlvez, J. Universidad de Zaragoza (orcid)0000-0002-7093-228X A unifying modelling formalism for the integration of stoichiometric and kinetic models 2020 Current research on systems and synthetic biology relies heavily on mathematical models of the systems under study. The usefulness of such models depends on the quantity and quality of biological data, and on the availability of appropriate modelling formalisms that can gather and accommodate such data so that they can be exploited properly. Given our incomplete knowledge of biological systems and the fact that they consist of many subsystems, biological data are usually uncertain and heterogeneous. These facts hinder the use of mathematical models and computational methods. In the scope of dynamic biological systems, e.g. metabolic networks, this difficulty can be overcome by the novel modelling formalism of flexible nets (FNs). We show that an FN can combine, in a natural way, a stoichiometric model and a kinetic model. Moreover, the resulting net admits nonlinear dynamics and can be analysed in both transient and steady states. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.118 2020 MULTIDISCIPLINARY SCIENCES 18 / 71 = 0.254 2020 Q2 T1 1.655 2020 Biochemistry 2020 Q1 Bioengineering 2020 Q1 Biotechnology 2020 Q1 Biomedical Engineering 2020 Q1 Biophysics 2020 Q1 Biomaterials 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Oliver, S.G. 5007 570 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Lenguajes y Sistemas Inf. 17, 169 (2020), 20200341 J. R. Soc. Interface Journal of the Royal Society Interface 1742-5689 505320 http://zaguan.unizar.es/record/147753/files/texto_completo.pdf Postprint 2544333 http://zaguan.unizar.es/record/147753/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:147753 articulos driver 2025-01-03-13:20:48 ARTICLE