000147815 001__ 147815
000147815 005__ 20250107161405.0
000147815 0247_ $$2doi$$a10.1111/bjh.12990
000147815 0248_ $$2sideral$$a129721
000147815 037__ $$aART-2014-129721
000147815 041__ $$aeng
000147815 100__ $$aAlvarez-Larrán, Alberto
000147815 245__ $$aWHO-histological criteria for myeloproliferative neoplasms: reproducibility, diagnostic accuracy and correlation with gene mutations and clinical outcomes
000147815 260__ $$c2014
000147815 5203_ $$aBone marrow histology is included in the diagnostic criteria of myeloproliferative neoplasms (MPNs). However, some concerns have emerged about its reproducibility. To evaluate the diagnostic accuracy of histology and to assess its correlation with presence of mutations and clinical outcomes, two pathologists reviewed the bone marrow biopsies corresponding to 211 patients with MPN. Despite the low agreement in the evaluation of individual histopathological characteristics, the concordance among pathologists when establishing the diagnosis was good (Kappa index 0·67). The specificity of histology was 100%, 98·5% and 98% in polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF), respectively, whereas the sensitivity of histological diagnosis was low in PV and ET (32·5% and 54% respectively) and acceptable in PMF (75%). Thirteen out of 146 (9%) patients with clinical ET were diagnosed as prefibrotic PMF. No histological agreement or MPN otherwise unspecified was more frequently observed in JAK2 V617F-positive ET than in CALR-mutated cases, whereas megakaryocytic abnormalities and prefibrotic PMF were more frequently observed in CALR-mutated ET. In conclusion, histological criteria of MPN have a limited diagnostic accuracy due to low sensitivity. Patients with JAK2 V617F-positive MPN have a heterogeneous histology while CALR-positive ET is associated with megakaryocyte abnormalities and prefibrotic PMF.
000147815 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000147815 590__ $$a4.711$$b2014
000147815 591__ $$aHEMATOLOGY$$b12 / 68 = 0.176$$c2014$$dQ1$$eT1
000147815 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147815 700__ $$aAncochea, Agueda
000147815 700__ $$0(orcid)0000-0003-2078-8205$$aGarcía, Mar
000147815 700__ $$aCliment, Fina
000147815 700__ $$aGarcía-Pallarols, Francesc
000147815 700__ $$aAngona, Anna
000147815 700__ $$aSenín, Alicia
000147815 700__ $$aBarranco, Carlos
000147815 700__ $$aMartínez-Avilés, Luz
000147815 700__ $$aSerrano, Sergio
000147815 700__ $$aBellosillo, Beatriz
000147815 700__ $$aBesses, Carlos
000147815 773__ $$g166, 6 (2014), 911-919$$pBr. j. haematol.$$tBRITISH JOURNAL OF HAEMATOLOGY$$x0007-1048
000147815 8564_ $$s101336$$uhttps://zaguan.unizar.es/record/147815/files/texto_completo.pdf$$yVersión publicada
000147815 8564_ $$s2602153$$uhttps://zaguan.unizar.es/record/147815/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147815 909CO $$ooai:zaguan.unizar.es:147815$$particulos$$pdriver
000147815 951__ $$a2025-01-07-14:05:34
000147815 980__ $$aARTICLE