000147841 001__ 147841
000147841 005__ 20250109150035.0
000147841 0247_ $$2doi$$a10.1038/leu.2014.184
000147841 0248_ $$2sideral$$a129720
000147841 037__ $$aART-2014-129720
000147841 041__ $$aeng
000147841 100__ $$aFernández-Rodríguez, C
000147841 245__ $$aMYD88 (L265P) mutation is an independent prognostic factor for outcome in patients with diffuse large B-cell lymphoma
000147841 260__ $$c2014
000147841 5203_ $$aDiffuse large B-cell lymphoma (DLBCL) encompasses an aggressive and heterogeneous group of malignancies. Gene expression profiling (GEP) unraveled two main subtypes based on their putative cell of origin named germinal center B-cell-like (GCB) and activated B-cell-like (ABC), with specific genetic alterations and different clinical outcome. Recent studies have reported several somatic mutations in the myeloid differentiation primary response gene 88 (MYD88) affecting B-cell lymphomas. Among them, the leucine to proline exchange at position 265 (L265P) is the most recurrent and biologically potent MYD88 variation, being found in about 30% of ABC-DLBCL but uncommon in GCB-DLBCL. Here, we have investigated the occurrence of MYD88 L265P mutation in adult patients with DLBCL and its relation to clinical and biological characteristics, including patients’ outcome.
000147841 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000147841 590__ $$a10.431$$b2014
000147841 591__ $$aONCOLOGY$$b9 / 209 = 0.043$$c2014$$dQ1$$eT1
000147841 591__ $$aHEMATOLOGY$$b3 / 68 = 0.044$$c2014$$dQ1$$eT1
000147841 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion
000147841 700__ $$aBellosillo, B
000147841 700__ $$0(orcid)0000-0003-2078-8205$$aGarcía-García, M
000147841 700__ $$aSánchez-González, B
000147841 700__ $$aGimeno, E
000147841 700__ $$aVela, M C
000147841 700__ $$aSerrano, S
000147841 700__ $$aBesses, C
000147841 700__ $$aSalar, A
000147841 773__ $$g28, 10 (2014), 2104-2106$$pLeukemia$$tLeukemia$$x0887-6924
000147841 8564_ $$s217252$$uhttps://zaguan.unizar.es/record/147841/files/texto_completo.pdf$$yVersión publicada
000147841 8564_ $$s2059121$$uhttps://zaguan.unizar.es/record/147841/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147841 909CO $$ooai:zaguan.unizar.es:147841$$particulos$$pdriver
000147841 951__ $$a2025-01-09-14:59:04
000147841 980__ $$aARTICLE