000147842 001__ 147842
000147842 005__ 20250108101618.0
000147842 0247_ $$2doi$$a10.3390/jcm11164886
000147842 0248_ $$2sideral$$a130182
000147842 037__ $$aART-2022-130182
000147842 041__ $$aeng
000147842 100__ $$aCasara, Alvise
000147842 245__ $$aChronic Bronchitis Affects Outcomes in Smokers without Chronic Obstructive Pulmonary Disease (COPD)
000147842 260__ $$c2022
000147842 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147842 5203_ $$aBackground. Chronic bronchitis (CB) importantly affects outcomes in smokers with COPD, but the effects on smokers without COPD are less well known and less emphasized. The aim of our study was to investigate the possible effects of CB on clinical outcomes in smokers without COPD (noCOPD) and compare them with the effects in smokers with COPD (COPD). Methods. For that purpose, we studied 511 smokers, 302 with and 209 without COPD, followed for 10 years in an academic COPD ambulatory setting. Chronic bronchitis was defined as the presence of cough and sputum production for at least 3 months in each of two consecutive years. All subjects underwent clinical and functional examination with spirometry, diffusion capacity (DLco), 6-min walking test (6MWT), mMRC Dyspnoea Scale, COPD Assessment Test (CAT), and recording of annual frequency of exacerbations. All-cause mortality during follow-up was recorded. Results. 27% of noCOPD and 45% of COPD had CB. noCOPD with CB had lower FEV1 and DLco, worse 6MWT, more dyspnoea, a higher number of exacerbations and lower survival than noCOPD without CB. CB did not affect FEV1 decline in noCOPD but it significantly did in COPD. Conclusions. The presence of chronic bronchitis in smokers without COPD will significantly affect symptoms, quality of life, and survival, underlining the importance of recognizing the condition and managing it accordingly.
000147842 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000147842 590__ $$a3.9$$b2022
000147842 591__ $$aMEDICINE, GENERAL & INTERNAL$$b58 / 169 = 0.343$$c2022$$dQ2$$eT2
000147842 592__ $$a0.935$$b2022
000147842 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000147842 594__ $$a5.4$$b2022
000147842 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147842 700__ $$aTurato, Graziella
000147842 700__ $$aMarin-Oto, Marta$$uUniversidad de Zaragoza
000147842 700__ $$aSemenzato, Umberto
000147842 700__ $$aBiondini, Davide
000147842 700__ $$aTine, Mariaenrica
000147842 700__ $$aBernardinello, Nicol
000147842 700__ $$aCocconcelli, Elisabetta
000147842 700__ $$aCubero, Pablo
000147842 700__ $$aBalestro, Elisabetta
000147842 700__ $$aSpagnolo, Paolo
000147842 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, Jose M.$$uUniversidad de Zaragoza
000147842 700__ $$aCosio, Manuel G.
000147842 700__ $$aSaetta, Marina
000147842 700__ $$aBazzan, Erica
000147842 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000147842 773__ $$g11, 16 (2022), 4886 [12 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000147842 8564_ $$s712751$$uhttps://zaguan.unizar.es/record/147842/files/texto_completo.pdf$$yVersión publicada
000147842 8564_ $$s2733296$$uhttps://zaguan.unizar.es/record/147842/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147842 909CO $$ooai:zaguan.unizar.es:147842$$particulos$$pdriver
000147842 951__ $$a2025-01-08-09:01:52
000147842 980__ $$aARTICLE