000147851 001__ 147851
000147851 005__ 20250108101618.0
000147851 0247_ $$2doi$$a10.1186/s12931-021-01633-y
000147851 0248_ $$2sideral$$a141365
000147851 037__ $$aART-2021-141365
000147851 041__ $$aeng
000147851 100__ $$aCalle Rubio, Myriam
000147851 245__ $$aCOPD Clinical Control: predictors and long-term follow-up of the CHAIN cohort
000147851 260__ $$c2021
000147851 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147851 5203_ $$aControl in COPD is a dynamic concept that can reflect changes in patients’ clinical status that may have prognostic implications, but there is no information about changes in control status and its long-term consequences.
Methods: We classified 798 patients with COPD from the CHAIN cohort as controlled/uncontrolled at baseline and over 5 years. We describe the changes in control status in patients over long-term follow-up and analyze the factors that were associated with longitudinal control patterns and related survival using the Cox hazard analysis
Results: 134 patients (16.8%) were considered persistently controlled, 248 (31.1%) persistently uncontrolled and 416 (52.1%) changed control status during follow-up. The variables significantly associated with persistent control were not requiring triple therapy at baseline and having a better quality of life. Annual changes in outcomes (health status, psychological status, airflow limitation) did not differ in patients, regardless of clinical control status. All-cause mortality was lower in persistently controlled patients (5.5% versus 19.1%, p = 0.001). The hazard ratio for all-cause mortality was 2.274 (95% CI 1.394–3.708; p = 0.001). Regarding pharmacological treatment, triple inhaled therapy was the most common option in persistently uncontrolled patients (72.2%). Patients with persistent disease control more frequently used bronchodilators for monotherapy (53%) at recruitment, although by the end of the follow-up period, 20% had scaled up their treatment, with triple therapy being the most frequent therapeutic pattern.
Conclusions: The evaluation of COPD control status provides relevant prognostic information on survival. There is important variability in clinical control status and only a small proportion of the patients had persistently good control. Changes in the treatment pattern may be relevant in the longitudinal pattern of COPD clinical control. Further studies in other populations should validate our results
Trial registration: Clinical Trials.gov: identifier NCT01122758.
000147851 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000147851 590__ $$a7.162$$b2021
000147851 591__ $$aRESPIRATORY SYSTEM$$b12 / 66 = 0.182$$c2021$$dQ1$$eT1
000147851 592__ $$a1.813$$b2021
000147851 593__ $$aPulmonary and Respiratory Medicine$$c2021$$dQ1
000147851 594__ $$a8.9$$b2021
000147851 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147851 700__ $$aRodriguez Hermosa, Juan Luis
000147851 700__ $$ade Torres, Juan P.
000147851 700__ $$0(orcid)0000-0001-9096-2294$$aMarín, José María$$uUniversidad de Zaragoza
000147851 700__ $$aMartínez-González, Cristina
000147851 700__ $$aFuster, Antonia
000147851 700__ $$aCosío, Borja G.
000147851 700__ $$aPeces-Barba, Germán
000147851 700__ $$aSolanes, Ingrid
000147851 700__ $$aFeu-Collado, Nuria
000147851 700__ $$aLopez-Campos, Jose Luis
000147851 700__ $$aCasanova, Ciro
000147851 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000147851 773__ $$g22 (2021), 36 [12 pp.]$$pRespir. res.$$tRespiratory Research$$x1465-9921
000147851 8564_ $$s1406991$$uhttps://zaguan.unizar.es/record/147851/files/texto_completo.pdf$$yVersión publicada
000147851 8564_ $$s2500291$$uhttps://zaguan.unizar.es/record/147851/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147851 909CO $$ooai:zaguan.unizar.es:147851$$particulos$$pdriver
000147851 951__ $$a2025-01-08-09:02:02
000147851 980__ $$aARTICLE