000147881 001__ 147881
000147881 005__ 20250109162738.0
000147881 0247_ $$2doi$$a10.5664/jcsm.9760
000147881 0248_ $$2sideral$$a141361
000147881 037__ $$aART-2021-141361
000147881 041__ $$aeng
000147881 100__ $$aMasa, Juan F.
000147881 245__ $$aRisk factors associated with pulmonary hypertension in obesity hypoventilation syndrome
000147881 260__ $$c2021
000147881 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147881 5203_ $$aStudy Objectives:
Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS.
Methods:
In a post hoc analysis of the Pickwick trial, we performed a bivariate analysis of baseline characteristics between patients with and without PH. Variables with a P value ≤ .10 were defined as potential risk factors and were grouped by theoretical pathogenic mechanisms in several adjusted models. Similar analysis was carried out for the 2 OHS phenotypes, with and without severe concomitant obstructive sleep apnea.
Results:
Of 246 patients with OHS, 122 (50%) had echocardiographic evidence of PH defined as systolic pulmonary artery pressure ≥ 40 mm Hg. Lower levels of awake PaO2 and higher body mass index were independent risk factors in the multivariate model, with a negative and positive adjusted linear association, respectively (adjusted odds ratio 0.96; 95% confidence interval 0.93 to 0.98; P = .003 for PaO2, and 1.07; 95% confidence interval 1.03 to 1.12; P = .001 for body mass index). In separate analyses, body mass index and PaO2 were independent risk factors in the severe obstructive sleep apnea phenotype, whereas body mass index and peak in-flow velocity in early/late diastole ratio were independent risk factors in the nonsevere obstructive sleep apnea phenotype.
Conclusions:
This study identifies obesity per se as a major independent risk factor for PH, regardless of OHS phenotype. Therapeutic interventions targeting weight loss may play a critical role in improving PH in this patient population.
000147881 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000147881 590__ $$a4.324$$b2021
000147881 591__ $$aCLINICAL NEUROLOGY$$b80 / 212 = 0.377$$c2021$$dQ2$$eT2
000147881 592__ $$a0.866$$b2021
000147881 593__ $$aNeurology (clinical)$$c2021$$dQ2
000147881 593__ $$aNeurology$$c2021$$dQ2
000147881 594__ $$a5.7$$b2021
000147881 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000147881 700__ $$aBenítez, Iván D.
000147881 700__ $$aJavaheri, Shahrokh
000147881 700__ $$aMogollon, Maria Victoria
000147881 700__ $$aSánchez-Quiroga, Maria Á.
000147881 700__ $$ade Terreros, Francisco J. Gomez
000147881 700__ $$aCorral, Jaime
000147881 700__ $$aGallego, Rocio
000147881 700__ $$aRomero, Auxiliadora
000147881 700__ $$aCaballero-Eraso, Candela
000147881 700__ $$aOrdax-Carbajo, Estrella
000147881 700__ $$aTroncoso, María F.
000147881 700__ $$aGonzález, Mónica
000147881 700__ $$aLópez-Martín, Soledad
000147881 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, José M.$$uUniversidad de Zaragoza
000147881 700__ $$aMartí, Sergi
000147881 700__ $$aDíaz-Cambriles, Trinidad
000147881 700__ $$aChiner, Eusebi
000147881 700__ $$aEgea, Carlos
000147881 700__ $$aBarca, Javier
000147881 700__ $$aBarbé, Ferrán
000147881 700__ $$aMokhlesi, Babak
000147881 700__ $$aUtrabo, Isabel
000147881 700__ $$aGonzález-Mangado, Nicolás
000147881 700__ $$aMartinez-Martinez, Maria A.
000147881 700__ $$aOjeda-Castillejo, Elena
000147881 700__ $$aLópez-Padilla, Daniel
000147881 700__ $$aCarrizo, Santiago J.
000147881 700__ $$aGallego, Begoña
000147881 700__ $$aPallero, Mercedes
000147881 700__ $$aRomero, Odile
000147881 700__ $$aRamón, Maria A.
000147881 700__ $$aArias, Eva
000147881 700__ $$aMuñoz-Méndez, Jesús
000147881 700__ $$aSenent, Cristina
000147881 700__ $$aSancho-Chust, Jose N.
000147881 700__ $$aNavarro-Soriano, Nieves B.
000147881 700__ $$aBarrot, Emilia
000147881 700__ $$aBenítez, José M.
000147881 700__ $$aSanchez-Gómez, Jesús
000147881 700__ $$aGolpe, Rafael
000147881 700__ $$aGómez-Mendieta, María A.
000147881 700__ $$aGomez, Silvia
000147881 700__ $$aBengoa, Mónica
000147881 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000147881 773__ $$g18, 4 (2021), 983-992$$pJOURNAL OF CLINICAL SLEEP MEDICINE$$tJOURNAL OF CLINICAL SLEEP MEDICINE$$x1550-9389
000147881 8564_ $$s437253$$uhttps://zaguan.unizar.es/record/147881/files/texto_completo.pdf$$yPostprint
000147881 8564_ $$s1405702$$uhttps://zaguan.unizar.es/record/147881/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000147881 909CO $$ooai:zaguan.unizar.es:147881$$particulos$$pdriver
000147881 951__ $$a2025-01-09-14:41:09
000147881 980__ $$aARTICLE