000147891 001__ 147891
000147891 005__ 20250109162738.0
000147891 0247_ $$2doi$$a10.1186/s12931-022-02191-7
000147891 0248_ $$2sideral$$a141356
000147891 037__ $$aART-2022-141356
000147891 041__ $$aeng
000147891 100__ $$aDivo, Miguel J.
000147891 245__ $$aComorbidities and mortality risk in adults younger than 50 years of age with chronic obstructive pulmonary disease
000147891 260__ $$c2022
000147891 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147891 5203_ $$aAbstract
Rationale and objective: Patients with chronic obstructive pulmonary disease (COPD), usually diagnosed after the 6th decade, frequently suffer from comorbidities. Whether COPD patients 50 years or younger (Young COPD) have similar comorbidities with the same frequency and mortality impact as aged-matched controls or older COPD patients is unknown.
Methods
We compared comorbidity number, prevalence and type in 3 groups of individuals with ≥ 10 pack-years of smoking: A Young (≤ 50 years) COPD group (n = 160), an age-balanced control group without airflow obstruction (n = 125), and Old (> 50 years) COPD group (n = 1860). We also compared survival between the young COPD and control subjects. Using Cox proportional model, we determined the comorbidities associated with mortality risk and generated Comorbidomes for the “Young” and “Old” COPD groups.
Results
The severity distribution by GOLD spirometric stages and BODE quartiles were similar between Young and Old COPD groups. After adjusting for age, sex, and pack-years, the prevalence of subjects with at least one comorbidity was 31% for controls, 77% for the Young, and 86% for older COPD patients. Compared to controls, “Young” COPDs’ had a nine-fold increased mortality risk (p < 0.0001). “Comorbidomes” differed between Young and Old COPD groups, with tuberculosis, substance use, and bipolar disorders being distinct comorbidities associated with increased mortality risk in the Young COPD group.
Conclusions
Young COPD patients carry a higher comorbidity prevalence and mortality risk compared to non-obstructed control subjects. Young COPD differed from older COPD patients by the behavioral-related comorbidities that increase their risk of premature death.
000147891 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000147891 590__ $$a5.8$$b2022
000147891 591__ $$aRESPIRATORY SYSTEM$$b15 / 66 = 0.227$$c2022$$dQ1$$eT1
000147891 592__ $$a1.753$$b2022
000147891 593__ $$aPulmonary and Respiratory Medicine$$c2022$$dQ1
000147891 594__ $$a9.5$$b2022
000147891 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147891 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, José M.$$uUniversidad de Zaragoza
000147891 700__ $$aCasanova, Ciro
000147891 700__ $$aCabrera Lopez, Carlos
000147891 700__ $$aPinto-Plata, Victor M.
000147891 700__ $$aMarin-Oto, Marta$$uUniversidad de Zaragoza
000147891 700__ $$aPolverino, Francesca
000147891 700__ $$ade-Torres, Juan P.
000147891 700__ $$aBillheimer, Dean
000147891 700__ $$aCelli, Bartolome R.
000147891 700__ $$aCelli, Bartolome R.
000147891 700__ $$aMarin, José M.
000147891 700__ $$aMacario, Ciro Casanova
000147891 700__ $$aPinto-Plata, Victor
000147891 700__ $$ade-Torres, Juan Pablo
000147891 700__ $$aDivo, Miguel J.
000147891 700__ $$aLopez, Carlos Cabrera
000147891 700__ $$aPolverino, Francesca
000147891 700__ $$aOto, Marta Marin
000147891 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000147891 773__ $$g23, 1 (2022), 267 [10 pp.]$$pRespir. res.$$tRespiratory Research$$x1465-9921
000147891 8564_ $$s1230409$$uhttps://zaguan.unizar.es/record/147891/files/texto_completo.pdf$$yVersión publicada
000147891 8564_ $$s2275531$$uhttps://zaguan.unizar.es/record/147891/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147891 909CO $$ooai:zaguan.unizar.es:147891$$particulos$$pdriver
000147891 951__ $$a2025-01-09-14:41:20
000147891 980__ $$aARTICLE