000147893 001__ 147893
000147893 005__ 20250908131421.0
000147893 0247_ $$2doi$$a10.3390/cimb46120850
000147893 0248_ $$2sideral$$a141504
000147893 037__ $$aART-2024-141504
000147893 041__ $$aeng
000147893 100__ $$0(orcid)0000-0001-8323-0984$$aAzúa-Romeo, Francisco Javier$$uUniversidad de Zaragoza
000147893 245__ $$aAdvances in the diagnosis of atypical polypoid adenomyoma combining immunohistochemical and molecular-based approaches: case report and review of the literature
000147893 260__ $$c2024
000147893 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147893 5203_ $$aAtypical polypoid adenomyoma (APA) is a benign uterine lesion with a premalignant potential and occurs in women of reproductive age. The histological pattern is characterized by irregular epithelial proliferation and muscular stroma. Based on a case report, we performed a systematic review of the literature to assess the main immunohistochemical and molecular markers that contribute to its differential diagnosis against endometrial adenocarcinoma (EC). The distinction is essential for offering to patients a conservative treatment compared to the radical management required for endometrial cancer, a critical issue for the significant physical and psychological consequences that one procedure or another can have on women’s health. We performed a meta-analysis of the immunohistochemical markers used for the histological diagnosis of APA, comparing it with our case study. The evaluated markers were beta-catenin, h-caldesmon, desmin, vimentin, smooth muscle alpha-actin, CD10, Ki67, estrogen receptor (ER), progesterone receptor (PR), pan-cytokeratin, PTEN, PMS2, MSH2, MSH6, p53, MLH1, and p16. Discrepancies were observed in the expression of CD10, h- caldesmon, and p16 when comparing APA with EC. The results of the case evaluated by our team showed beta-catenin nuclear expression and positive immunostaining for pan-cytokeratin, ER, and PR in the glands; smooth muscle actin and desmin positive expression in stromal muscle; and p16 positive immunostaining in squamous morules. Moreover, the c.94G>T p. (Asp132Tyr) mutation in the CTNNB1 gene was detected. This study supports the combination of appropriate immunohistochemical and molecular markers, along with the presumptive histological diagnosis, and determines the correct classification of the lesion as APA and not as other malignant pathologies, allowing for the establishment of a treatment protocol adjusted to the biological reality of this pathology.
000147893 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000147893 592__ $$a0.791$$b2024
000147893 593__ $$aMedicine (miscellaneous)$$c2024$$dQ2
000147893 593__ $$aMicrobiology$$c2024$$dQ2
000147893 593__ $$aMicrobiology (medical)$$c2024$$dQ2
000147893 593__ $$aMolecular Biology$$c2024$$dQ3
000147893 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147893 700__ $$aBayona-Morón, Sonia
000147893 700__ $$aRodriguez-Pérez, Irene
000147893 700__ $$aAngulo-Biedma, Bárbara
000147893 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000147893 773__ $$g46, 12 (2024), 14204-14214$$tCurrent Issues in Molecular Biology$$x1467-3045
000147893 8564_ $$s2782745$$uhttps://zaguan.unizar.es/record/147893/files/texto_completo.pdf$$yVersión publicada
000147893 8564_ $$s2748460$$uhttps://zaguan.unizar.es/record/147893/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147893 909CO $$ooai:zaguan.unizar.es:147893$$particulos$$pdriver
000147893 951__ $$a2025-09-08-12:53:09
000147893 980__ $$aARTICLE