Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease

Callejón-Leblic, Belén ; Sánchez Espirilla, Saida ; Gotera-Rivera, Carolina ; Santana, Rafael ; Díaz-Olivares, Isabel ; Marín, José M. (Universidad de Zaragoza) ; Macario, Ciro Casanova ; Cosio, Borja García ; Fuster, Antonia ; García, Ingrid Solanes ; de-Torres, Juan P. ; Feu Collado, Nuria ; Cabrera Lopez, Carlos ; Amado Diago, Carlos ; Romero Plaza, Amparo ; Fraysse, Luis Alejandro Padrón ; Márquez Martín, Eduardo ; Marín Royo, Margarita ; Balcells Vilarnau, Eva ; Llunell Casanovas, Antonia ; Martínez González, Cristina ; Galdíz Iturri, Juan Bautista ; Lacárcel Bautista, Celia ; Gómez-Ariza, José Luis ; Pereira-Vega, Antonio ; Seijo, Luis ; López-Campos, José Luis ; Peces-Barba, Germán ; García-Barrera, Tamara

Resumen: Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.

Idioma: Inglés

DOI: 10.3390/ijms241814250

Año: 2023

Publicado en: International Journal of Molecular Sciences 24, 18 (2023), 14250 [14 pp.]
ISSN: 1661-6596

Factor impacto JCR: 4.9 (2023)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 66 / 313 = 0.211 (2023) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 68 / 231 = 0.294 (2023) - Q2 - T1

Factor impacto CITESCORE: 8.1 - Physical and Theoretical Chemistry (Q1) - Organic Chemistry (Q1) - Computer Science Applications (Q1) - Inorganic Chemistry (Q1) - Spectroscopy (Q1) - Catalysis (Q2) - Molecular Biology (Q2)

Factor impacto SCIMAGO: 1.179 - Medicine (miscellaneous) (Q1) - Physical and Theoretical Chemistry (Q1) - Computer Science Applications (Q1) - Inorganic Chemistry (Q1) - Spectroscopy (Q1) - Organic Chemistry (Q1) - Molecular Biology (Q2) - Catalysis (Q2)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)