000147907 001__ 147907
000147907 005__ 20250109162738.0
000147907 0247_ $$2doi$$a10.3390/biom14121641
000147907 0248_ $$2sideral$$a141428
000147907 037__ $$aART-2024-141428
000147907 041__ $$aeng
000147907 100__ $$0(orcid)0009-0008-3380-0465$$aGascón, Elisa$$uUniversidad de Zaragoza
000147907 245__ $$aIdentifying Hub Genes and miRNAs Associated with Alzheimer’s Disease: A Bioinformatics Pathway to Novel Therapeutic Strategies
000147907 260__ $$c2024
000147907 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147907 5203_ $$aAlzheimer’s disease (AD) is a neurodegenerative disorder that mainly affects the elderly population. It is characterized by cognitive impairment and dementia due to abnormal levels of amyloid beta peptide (Aβ) and axonal Tau protein in the brain. However, the complex underlying mechanisms affecting this disease are not yet known, and there is a lack of standardized biomarkers and therapeutic targets. Therefore, in this study, by means of bioinformatics analysis, AD-affected brain tissue was analyzed using the GSE138260 dataset, identifying 612 differentially expressed genes (DEGs). Functional analysis revealed 388 upregulated DEGs associated with sensory perception and 224 downregulated DEGs linked to the regulation and modulation of synaptic processes. Protein–protein interaction network analysis identified 20 hub genes. Furthermore, miRNA target gene networks revealed 1767 miRNAs linked to hub genes, among which hsa-mir-106a-5p, hsa-mir-17-5p, hsa-mir-26a-5p, hsa-mir-27a-3p and hsa-mir-34a-5p were the most relevant. This study presents novel biomarkers and therapeutic targets for AD by analyzing the information obtained with a comprehensive literature review, providing new potential targets to study their role in AD.
000147907 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A19-23R$$9info:eu-repo/grantAgreement/ES/FIS-FEDER/PI17-00949
000147907 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000147907 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147907 700__ $$0(orcid)0000-0001-5193-7782$$aCalvo, Ana Cristina$$uUniversidad de Zaragoza
000147907 700__ $$aMolina, Nora$$uUniversidad de Zaragoza
000147907 700__ $$0(orcid)0000-0001-5740-0185$$aZaragoza, Pilar$$uUniversidad de Zaragoza
000147907 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, Rosario$$uUniversidad de Zaragoza
000147907 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000147907 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000147907 773__ $$g14, 12 (2024), 1641 [14 pp.]$$tBiomolecules$$x2218-273X
000147907 8564_ $$s2484411$$uhttps://zaguan.unizar.es/record/147907/files/texto_completo.pdf$$yVersión publicada
000147907 8564_ $$s2779685$$uhttps://zaguan.unizar.es/record/147907/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147907 909CO $$ooai:zaguan.unizar.es:147907$$particulos$$pdriver
000147907 951__ $$a2025-01-09-14:41:38
000147907 980__ $$aARTICLE