000147922 001__ 147922
000147922 005__ 20250109162738.0
000147922 0247_ $$2doi$$a10.1183/23120541.00202-2022
000147922 0248_ $$2sideral$$a141357
000147922 037__ $$aART-2022-141357
000147922 041__ $$aeng
000147922 100__ $$aBazzan, Erica
000147922 245__ $$aSymptomatic smokers without COPD have physiological changes heralding the development of COPD
000147922 260__ $$c2022
000147922 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147922 5203_ $$aCOPD is a major health problem, mainly due to cigarette smoking. Most studies in COPD are dedicated to fully developed COPD in older subjects, even though development of COPD may start soon after smoking initiation. Therefore, there is a need to diagnose this “early disease” by detecting the initial events responsible for ultimate development of COPD.MethodsMeasurement of maximum mid expiratory flow between 25 and 75% of vital capacity (MMEF) in a routine spirometry, which detects small airways disease, was used to investigate if MMEF abnormalities in smokers without COPD (noCOPD) would relate to respiratory symptoms and identify smokers that might progress to COPD. For this purpose we studied 511 smokers, 302 COPD and 209 noCOPD, followed long term with spirometry including MMEF, diffusing capacity of the lung for carbon monoxide (DLCO), 6-min walk test (6MWT), Medical Research Council Dyspnoea Scale and COPD Assessment Test. Three spirometries V1,V2 and V3 (5±2.5 and 10±4 years apart from V1) were performed to assess functional decline and development of COPD.Results65% of noCOPD had an abnormal MMEF (<80%) and 38% an abnormalDLCO. The NoCOPD with MMEF <80% group performed worse in the 6MWT (p=0.01), was more dyspnoeic (p=0.01) and had higher prevalence of chronic bronchitis than the noCOPD with MMEF>80% group (p=0.04). 21% of noCOPD with MMEF <80% and 2.7% with MMEF>80% developed COPD by V3 (p=0.0004).ConclusionsThe MMEF, a functional test available in a routine spirometry, can detect early lung abnormalities and identify the subset of symptomatic smokers with pathological changes that might lead to COPD.
000147922 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000147922 590__ $$a4.6$$b2022
000147922 591__ $$aRESPIRATORY SYSTEM$$b22 / 66 = 0.333$$c2022$$dQ2$$eT2
000147922 592__ $$a1.304$$b2022
000147922 593__ $$aPulmonary and Respiratory Medicine$$c2022$$dQ1
000147922 594__ $$a5.2$$b2022
000147922 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147922 700__ $$aSemenzato, Umberto
000147922 700__ $$aTurato, Graziella
000147922 700__ $$aBiondini, Davide
000147922 700__ $$aCubero, Pablo
000147922 700__ $$aMarin-Oto, Marta$$uUniversidad de Zaragoza
000147922 700__ $$aForner, Marta
000147922 700__ $$aTinè, Mariaenrica
000147922 700__ $$aCasara, Alvise
000147922 700__ $$aBaraldo, Simonetta
000147922 700__ $$aSpagnolo, Paolo
000147922 700__ $$aMarin, Jose M.
000147922 700__ $$aSaetta, Marina
000147922 700__ $$aCosio, Manuel G.
000147922 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000147922 773__ $$g8, 2 (2022), [11 pp.]$$pERJ open res.$$tERJ Open Research$$x2312-0541
000147922 8564_ $$s578009$$uhttps://zaguan.unizar.es/record/147922/files/texto_completo.pdf$$yVersión publicada
000147922 8564_ $$s2560841$$uhttps://zaguan.unizar.es/record/147922/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147922 909CO $$ooai:zaguan.unizar.es:147922$$particulos$$pdriver
000147922 951__ $$a2025-01-09-14:41:53
000147922 980__ $$aARTICLE