000147981 001__ 147981
000147981 005__ 20250110163828.0
000147981 0247_ $$2doi$$a10.1016/j.ica.2017.06.047
000147981 0248_ $$2sideral$$a104565
000147981 037__ $$aART-2018-104565
000147981 041__ $$aeng
000147981 100__ $$aLippert, B.
000147981 245__ $$aComparing PtII- and PdII-nucleobase coordination chemistry: Why PdII not always is a good substitute for PtII
000147981 260__ $$c2018
000147981 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147981 5203_ $$aAs is well established, numerous similarities exist as far as reactivity patterns and structural features of the d8 metal ions M = Pd2+ and Pt2+ are concerned. Here reactions of metal complexes of type cis-[M(a)2X2] (a = NH3 or (a)2 = diamine or diimine; X = monodentate or X2 = bidentate leaving groups) with nucleobases, the constituents of nucleic acids, are discussed and differences regarding intrinsic stability of the starting compounds, kinetics of formation of products, thermodynamics of products, as well as donor site selectivity are pointed out. It is concluded that PdII complexes representing strict or close analogues of established antitumor PtII drugs of the Cisplatin-type, if active under in vivo conditions at all, are unlikely to have a similar mode of action as their PtII congeners. Relationships to supramolecular constructs containing cis-[M(a)2]2+ entities are likewise discussed.
000147981 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000147981 590__ $$a2.433$$b2018
000147981 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b16 / 45 = 0.356$$c2018$$dQ2$$eT2
000147981 592__ $$a0.455$$b2018
000147981 593__ $$aInorganic Chemistry$$c2018$$dQ2
000147981 593__ $$aPhysical and Theoretical Chemistry$$c2018$$dQ2
000147981 593__ $$aMaterials Chemistry$$c2018$$dQ2
000147981 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion
000147981 700__ $$0(orcid)0000-0002-8220-6031$$aSanz Miguel, P.J.$$uUniversidad de Zaragoza
000147981 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000147981 773__ $$g472 (2018), 207-213$$pInorg. Chim. Acta$$tINORGANICA CHIMICA ACTA$$x0020-1693
000147981 8564_ $$s373194$$uhttps://zaguan.unizar.es/record/147981/files/texto_completo.pdf$$yPostprint
000147981 8564_ $$s1575506$$uhttps://zaguan.unizar.es/record/147981/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000147981 909CO $$ooai:zaguan.unizar.es:147981$$particulos$$pdriver
000147981 951__ $$a2025-01-10-14:24:23
000147981 980__ $$aARTICLE