147981 20250110163828.0 doi 10.1016/j.ica.2017.06.047 sideral 104565 ART-2018-104565 eng Lippert, B. Comparing PtII- and PdII-nucleobase coordination chemistry: Why PdII not always is a good substitute for PtII 2018 As is well established, numerous similarities exist as far as reactivity patterns and structural features of the d8 metal ions M = Pd2+ and Pt2+ are concerned. Here reactions of metal complexes of type cis-[M(a)2X2] (a = NH3 or (a)2 = diamine or diimine; X = monodentate or X2 = bidentate leaving groups) with nucleobases, the constituents of nucleic acids, are discussed and differences regarding intrinsic stability of the starting compounds, kinetics of formation of products, thermodynamics of products, as well as donor site selectivity are pointed out. It is concluded that PdII complexes representing strict or close analogues of established antitumor PtII drugs of the Cisplatin-type, if active under in vivo conditions at all, are unlikely to have a similar mode of action as their PtII congeners. Relationships to supramolecular constructs containing cis-[M(a)2]2+ entities are likewise discussed. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.433 2018 CHEMISTRY, INORGANIC & NUCLEAR 16 / 45 = 0.356 2018 Q2 T2 0.455 2018 Inorganic Chemistry 2018 Q2 Physical and Theoretical Chemistry 2018 Q2 Materials Chemistry 2018 Q2 info:eu-repo/semantics/review info:eu-repo/semantics/acceptedVersion Sanz Miguel, P.J. Universidad de Zaragoza (orcid)0000-0002-8220-6031 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 472 (2018), 207-213 Inorg. Chim. Acta INORGANICA CHIMICA ACTA 0020-1693 373194 http://zaguan.unizar.es/record/147981/files/texto_completo.pdf Postprint 1575506 http://zaguan.unizar.es/record/147981/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:147981 articulos driver 2025-01-10-14:24:23 ARTICLE