000147991 001__ 147991
000147991 005__ 20250110163828.0
000147991 0247_ $$2doi$$a10.1016/j.envint.2019.105433
000147991 0248_ $$2sideral$$a116845
000147991 037__ $$aART-2020-116845
000147991 041__ $$aeng
000147991 100__ $$aDonat-Vargas, C.
000147991 245__ $$aExposure to dietary polychlorinated biphenyls and dioxins, and its relationship with subclinical coronary atherosclerosis: The Aragon Workers' Health Study
000147991 260__ $$c2020
000147991 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147991 5203_ $$aBackground: Experimental evidence has revealed that exposure to polychlorinated biphenyls (PCBs) and dioxins directly impairs endothelial function and induces atherosclerosis progression. In the general population, despite a small number of recent studies finding a link between PCBs, and stroke and myocardial infraction, the association with early coronary atherosclerosis has not been examined yet. Objective: To examine whether dietary exposure to PCBs and dioxins is associated with subclinical coronary atherosclerosis in a middle-aged men. Design: Cross-sectional analysis comprising 1844 men in their 50 s and free of cardiovascular disease, who participated in the Aragon Workers'' Health Study (AWHS). Individual dietary exposures to PCBs and dioxins were estimated by the contaminant''s concentration in food coupled with the corresponding consumption and then participants were classified into quartiles of consumption. Coronary artery calcium score (CACS) was assessed by computerized tomography. We conducted ordered logistic regressions to estimate the odds ratio (OR) and 95% confidence intervals (CIs) for progression to the categories of more coronary artery calcium, adjusting for potential confounders. Results: Among the participants, coronary calcium was not shown in 60.1% (n = 1108), 29.8% had a CACS > 0 and <100 (n = 550), and the remaining 10.1% (n = 186) had a CACS = 100. Compared with those in the first quartile of PCBs exposure, those in the fourth one had an increased odds for having coronary calcium (OR 2.02, 95% CI 1.18, 3.47], p trend 0.019) and for having progressed to categories of more intense calcification (OR 2.03, 95% CI 1.21, 3.40], p trend 0.012). However, no association was found between dietary dioxins exposure and prevalent coronary artery calcium. Conclusions: In this general male population, dietary exposure to PCBs, but not to dioxins, was associated with a higher prevalence of coronary calcium and to more intense subclinical coronary atherosclerosis. PCBs exposure seems to increase the risk of coronary disease in men from the very early stages. © 2019
000147991 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI17-1709$$9info:eu-repo/grantAgreement/EC/H2020/635316/EU/Ageing Trajectories of Health: Longitudinal Opportunities and Synergies/ATHLOS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 635316-ATHLOS$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PIE16-00022
000147991 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000147991 590__ $$a9.621$$b2020
000147991 591__ $$aENVIRONMENTAL SCIENCES$$b14 / 273 = 0.051$$c2020$$dQ1$$eT1
000147991 592__ $$a2.581$$b2020
000147991 593__ $$aEnvironmental Science (miscellaneous)$$c2020$$dQ1
000147991 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147991 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, B.$$uUniversidad de Zaragoza
000147991 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M.$$uUniversidad de Zaragoza
000147991 700__ $$aSandoval-Insausti, H.
000147991 700__ $$0(orcid)0000-0001-9142-0737$$aJarauta, E.$$uUniversidad de Zaragoza
000147991 700__ $$aGuallar-Castillon, P.
000147991 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000147991 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000147991 773__ $$g136 (2020), 105433 [8 pp]$$pEnviron. int.$$tENVIRONMENT INTERNATIONAL$$x0160-4120
000147991 85641 $$uhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85077464203&doi=10.1016%2fj.envint.2019.105433&partnerID=40&md5=c4d8dda466e58fd11196570f32204729$$zTexto completo de la revista
000147991 8564_ $$s219256$$uhttps://zaguan.unizar.es/record/147991/files/texto_completo.pdf$$yVersión publicada
000147991 8564_ $$s2165207$$uhttps://zaguan.unizar.es/record/147991/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147991 909CO $$ooai:zaguan.unizar.es:147991$$particulos$$pdriver
000147991 951__ $$a2025-01-10-14:24:39
000147991 980__ $$aARTICLE