147991 20250110163828.0 doi 10.1016/j.envint.2019.105433 sideral 116845 ART-2020-116845 eng Donat-Vargas, C. Exposure to dietary polychlorinated biphenyls and dioxins, and its relationship with subclinical coronary atherosclerosis: The Aragon Workers' Health Study 2020 Background: Experimental evidence has revealed that exposure to polychlorinated biphenyls (PCBs) and dioxins directly impairs endothelial function and induces atherosclerosis progression. In the general population, despite a small number of recent studies finding a link between PCBs, and stroke and myocardial infraction, the association with early coronary atherosclerosis has not been examined yet. Objective: To examine whether dietary exposure to PCBs and dioxins is associated with subclinical coronary atherosclerosis in a middle-aged men. Design: Cross-sectional analysis comprising 1844 men in their 50 s and free of cardiovascular disease, who participated in the Aragon Workers'' Health Study (AWHS). Individual dietary exposures to PCBs and dioxins were estimated by the contaminant''s concentration in food coupled with the corresponding consumption and then participants were classified into quartiles of consumption. Coronary artery calcium score (CACS) was assessed by computerized tomography. We conducted ordered logistic regressions to estimate the odds ratio (OR) and 95% confidence intervals (CIs) for progression to the categories of more coronary artery calcium, adjusting for potential confounders. Results: Among the participants, coronary calcium was not shown in 60.1% (n = 1108), 29.8% had a CACS > 0 and <100 (n = 550), and the remaining 10.1% (n = 186) had a CACS = 100. Compared with those in the first quartile of PCBs exposure, those in the fourth one had an increased odds for having coronary calcium (OR 2.02, 95% CI 1.18, 3.47], p trend 0.019) and for having progressed to categories of more intense calcification (OR 2.03, 95% CI 1.21, 3.40], p trend 0.012). However, no association was found between dietary dioxins exposure and prevalent coronary artery calcium. Conclusions: In this general male population, dietary exposure to PCBs, but not to dioxins, was associated with a higher prevalence of coronary calcium and to more intense subclinical coronary atherosclerosis. PCBs exposure seems to increase the risk of coronary disease in men from the very early stages. © 2019 Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/FIS/PI17-1709 info:eu-repo/grantAgreement/EC/H2020/635316/EU/Ageing Trajectories of Health: Longitudinal Opportunities and Synergies/ATHLOS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 635316-ATHLOS info:eu-repo/grantAgreement/ES/ISCIII/FIS/PIE16-00022 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 9.621 2020 ENVIRONMENTAL SCIENCES 14 / 273 = 0.051 2020 Q1 T1 2.581 2020 Environmental Science (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Moreno-Franco, B. Universidad de Zaragoza (orcid)0000-0003-0604-5042 Laclaustra, M. Universidad de Zaragoza (orcid)0000-0003-3963-0846 Sandoval-Insausti, H. Jarauta, E. Universidad de Zaragoza (orcid)0000-0001-9142-0737 Guallar-Castillon, P. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 136 (2020), 105433 [8 pp] Environ. int. ENVIRONMENT INTERNATIONAL 0160-4120 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077464203&doi=10.1016%2fj.envint.2019.105433&partnerID=40&md5=c4d8dda466e58fd11196570f32204729 Texto completo de la revista 219256 http://zaguan.unizar.es/record/147991/files/texto_completo.pdf Versión publicada 2165207 http://zaguan.unizar.es/record/147991/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:147991 articulos driver 2025-01-10-14:24:39 ARTICLE