000147999 001__ 147999
000147999 005__ 20250110163828.0
000147999 0247_ $$2doi$$a10.1021/acs.langmuir.1c00434
000147999 0248_ $$2sideral$$a127141
000147999 037__ $$aART-2021-127141
000147999 041__ $$aeng
000147999 100__ $$aJurak, M.
000147999 245__ $$aAnalysis of Molecular Interactions between Components in Phospholipid-Immunosuppressant-Antioxidant Mixed Langmuir Films
000147999 260__ $$c2021
000147999 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147999 5203_ $$aThe study of Langmuir monolayers incorporating biomimetic and bioactive substances plays an important role today in assessing the properties and quality of the molecular films for potential biomedical applications. Here, miscibility of binary and ternary monolayers of phospholipid (dioleoyl phosphatidylcholine, DOPC), immunosuppressant (cyclosporine A, CsA), and antioxidant (lauryl gallate, LG) of varying molar fractions was analyzed by means of the Langmuir technique coupled with a surface potential (?V) module at the air-water interface. The surface pressure-area per molecule (?-A) isotherms provided information on the physical state of the films at a given surface pressure, the monolayer packing and ordering, and the type and strength of intermolecular interactions. Surface potential-area (?V-A) isotherms revealed the molecular orientation changes at the interface upon compression. In addition, the apparent dipole moment of the monolayer-forming molecules was determined from the surface potential isotherms. The obtained results indicated that the film compression provoked subsequent changes of CsA conformation and/or orientation, conferring better affinity for the hydrocarbon environment. The mutual interactions between the components were analyzed here in terms of the excess and total Gibbs energy of mixing, whose values depended on the stoichiometry of the mixed films. The strongest attraction, thus the highest thermodynamic stability, was found for a DOPC-CsA-LG mixture with a 1:1:2 molar ratio. Based on these results, a molecular model for the organization of the molecules within the Langmuir film was proposed. Through this model, we elucidated the significant role of LG in improving the miscibility of CsA in the model DOPC membrane and thus in increasing the stability of self-assembled monolayers by noncovalent interactions, such as H-bonds and Lifshitz-van der Waals forces. The above 1:1:2 combination of three components is revealed as the most promising film composition for the modification of implant device surfaces to improve their biocompatibility. Further insight into mechanisms concerning drug-membrane interactions at the molecular level is provided, which results in great importance for biocoating design and development as well as for drug release at target sites. © 2021 American Chemical Society. All rights reserved.
000147999 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E21-20R$$9info:eu-repo/grantAgreement/EUR/ERA-NET-COFUND/MagicCellGene Project 2016$$9info:eu-repo/grantAgreement/ES/MINECO/PCIN-2017-127
000147999 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000147999 590__ $$a4.331$$b2021
000147999 591__ $$aCHEMISTRY, PHYSICAL$$b74 / 165 = 0.448$$c2021$$dQ2$$eT2
000147999 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b72 / 179 = 0.402$$c2021$$dQ2$$eT2
000147999 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b138 / 344 = 0.401$$c2021$$dQ2$$eT2
000147999 592__ $$a0.884$$b2021
000147999 593__ $$aCondensed Matter Physics$$c2021$$dQ1
000147999 593__ $$aElectrochemistry$$c2021$$dQ1
000147999 593__ $$aSurfaces and Interfaces$$c2021$$dQ1
000147999 593__ $$aSpectroscopy$$c2021$$dQ1
000147999 593__ $$aMaterials Science (miscellaneous)$$c2021$$dQ1
000147999 594__ $$a6.7$$b2021
000147999 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147999 700__ $$aSzafran, K.
000147999 700__ $$0(orcid)0000-0002-4729-9578$$aCea, P.$$uUniversidad de Zaragoza
000147999 700__ $$0(orcid)0000-0001-9193-3874$$aMartín, S.$$uUniversidad de Zaragoza
000147999 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000147999 773__ $$g37, 18 (2021), 5601-5616$$pLangmuir$$tLangmuir$$x0743-7463
000147999 8564_ $$s3381451$$uhttps://zaguan.unizar.es/record/147999/files/texto_completo.pdf$$yVersión publicada
000147999 8564_ $$s3024597$$uhttps://zaguan.unizar.es/record/147999/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147999 909CO $$ooai:zaguan.unizar.es:147999$$particulos$$pdriver
000147999 951__ $$a2025-01-10-14:24:52
000147999 980__ $$aARTICLE