000148010 001__ 148010
000148010 005__ 20250110163829.0
000148010 0247_ $$2doi$$a10.1038/s41598-022-23075-2
000148010 0248_ $$2sideral$$a130577
000148010 037__ $$aART-2022-130577
000148010 041__ $$aeng
000148010 100__ $$aPerez-Lasierra, Jose Luis
000148010 245__ $$aCardiorespiratory fitness decreases the odds for subclinical carotid plaques in apolipoprotein e4 homozygotes
000148010 260__ $$c2022
000148010 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148010 5203_ $$aSome studies suggest that being an apolipoprotein e4 (APOE e4) carrier increases the risk of atherosclerosis, and others suggest that cardiorespiratory fitness (CRF) could play a key role in atherosclerotic prevention. Our aim was to analyze the association of APOE e4 with carotid atherosclerosis and the association of CRF with atherosclerosis in APOE e4 carriers. A cross-sectional analysis based on a subsample of 90 participants in the Aragon Workers’ Health Study was carried out. Ultrasonography was used to assess the presence of plaques in carotid territory; the submaximal Chester Step Test was used to assess CRF; and behavioral, demographic, anthropometric, and clinical data were obtained by trained personnel during annual medical examinations. APOE e4e4 participants were categorized into Low-CRF (VO2max <= 35 mL/kg/min) and High-CRF (VO2max ≥ 35 mL/kg/min) groups. After adjusting for several confounders, compared with APOE e3e3, those participants genotyped as APOE e3e4 and APOE e4e4 showed an OR = 1.60 (95% CI 0.45, 5.71) and OR = 4.29 (95% CI 1.16, 15.91), respectively, for carotid atherosclerosis. Compared to Low-CRF APOE e4e4 carriers, the odds of carotid plaque detection were 0.09 (95% CI 0.008, 0.98) times lower among High-CRF APOE e4e4 carriers. The APOE e4e4 genotype was associated with increased carotid atherosclerosis. However, CRF is a modifiable factor that may be targeted by APOE e4e4 to decrease the elevation of atherosclerotic risk due to this genetic condition.
000148010 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B12-20R$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948$$9info:eu-repo/grantAgreement/ES/MECD/FPU16-02539
000148010 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000148010 590__ $$a4.6$$b2022
000148010 591__ $$aMULTIDISCIPLINARY SCIENCES$$b22 / 73 = 0.301$$c2022$$dQ2$$eT1
000148010 592__ $$a0.973$$b2022
000148010 593__ $$aMultidisciplinary$$c2022$$dQ1
000148010 594__ $$a7.5$$b2022
000148010 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148010 700__ $$aCasajús, José A.
000148010 700__ $$aGonzalez-Agüero, Alejandro
000148010 700__ $$aArbones-Mainar, José Miguel
000148010 700__ $$aCasasnovas, José A.
000148010 700__ $$aLaclaustra, Martin
000148010 700__ $$aMoreno-Franco, Belén
000148010 773__ $$g12, 1 (2022), 19496 [7 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000148010 8564_ $$s1096946$$uhttps://zaguan.unizar.es/record/148010/files/texto_completo.pdf$$yVersión publicada
000148010 8564_ $$s2530045$$uhttps://zaguan.unizar.es/record/148010/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148010 909CO $$ooai:zaguan.unizar.es:148010$$particulos$$pdriver
000148010 951__ $$a2025-01-10-14:25:09
000148010 980__ $$aARTICLE