148010 20250110163829.0 doi 10.1038/s41598-022-23075-2 sideral 130577 ART-2022-130577 eng Perez-Lasierra, Jose Luis Cardiorespiratory fitness decreases the odds for subclinical carotid plaques in apolipoprotein e4 homozygotes 2022 Some studies suggest that being an apolipoprotein e4 (APOE e4) carrier increases the risk of atherosclerosis, and others suggest that cardiorespiratory fitness (CRF) could play a key role in atherosclerotic prevention. Our aim was to analyze the association of APOE e4 with carotid atherosclerosis and the association of CRF with atherosclerosis in APOE e4 carriers. A cross-sectional analysis based on a subsample of 90 participants in the Aragon Workers’ Health Study was carried out. Ultrasonography was used to assess the presence of plaques in carotid territory; the submaximal Chester Step Test was used to assess CRF; and behavioral, demographic, anthropometric, and clinical data were obtained by trained personnel during annual medical examinations. APOE e4e4 participants were categorized into Low-CRF (VO2max <= 35 mL/kg/min) and High-CRF (VO2max ≥ 35 mL/kg/min) groups. After adjusting for several confounders, compared with APOE e3e3, those participants genotyped as APOE e3e4 and APOE e4e4 showed an OR = 1.60 (95% CI 0.45, 5.71) and OR = 4.29 (95% CI 1.16, 15.91), respectively, for carotid atherosclerosis. Compared to Low-CRF APOE e4e4 carriers, the odds of carotid plaque detection were 0.09 (95% CI 0.008, 0.98) times lower among High-CRF APOE e4e4 carriers. The APOE e4e4 genotype was associated with increased carotid atherosclerosis. However, CRF is a modifiable factor that may be targeted by APOE e4e4 to decrease the elevation of atherosclerotic risk due to this genetic condition. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/B12-20R info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948 info:eu-repo/grantAgreement/ES/MECD/FPU16-02539 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.6 2022 MULTIDISCIPLINARY SCIENCES 22 / 73 = 0.301 2022 Q2 T1 0.973 2022 Multidisciplinary 2022 Q1 7.5 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Casajús, José A. Gonzalez-Agüero, Alejandro Arbones-Mainar, José Miguel Casasnovas, José A. Laclaustra, Martin Moreno-Franco, Belén 12, 1 (2022), 19496 [7 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 1096946 http://zaguan.unizar.es/record/148010/files/texto_completo.pdf Versión publicada 2530045 http://zaguan.unizar.es/record/148010/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:148010 articulos driver 2025-01-10-14:25:09 ARTICLE